中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Pharmacokinetic and metabolite profile of orally administered anemoside B4 in rats with an improved exposure in formulations of rectal suppository
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 315, 页码: 11
作者:
Ye, Yaqing
;
Xue, Mingzhen
;
Tian, Xiaoting
;
Gao, Hongwei
;
Hu, Pei
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Anemoside B4
Pulsatilla chinensis
metabolite identification
Pharmacokinetics
Rectal suppository
Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221
作者:
He Yifei
;
Liu Yin
;
Yu Jinghua
;
Cheng Huan
;
Odilov Abdullajon
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/05/22
TPN171
14CTPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule
期刊论文
OAI收割
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023, 卷号: 225, 页码: 12
作者:
He, Liangliang
;
Chen, Chanjuan
;
Duan, Shuyi
;
Li, Yang
;
Li, Chuan
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/11/11
Xian-Ling-Gu-Bao capsule
Estrogens
Sulfotransferase enzymes
Inhibitory effects
Molecular docking
Changes in Disposition of Ezetimibe and Its Active Metabolites Induced by Impaired Hepatic Function: The Influence of Enzyme and Transporter Activities
期刊论文
OAI收割
PHARMACEUTICS, 2022, 卷号: 14, 期号: 12, 页码: 22
作者:
Xie, Ningjie
;
Wang, Hong
;
Qin, Hua
;
Guo, Zitao
;
Xue, Hao
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/04/10
hepatic impairment
ezetimibe
active metabolites
phase II enzymes
transporters
first-pass metabolism
inhibitory bile acids
Identification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 17
作者:
He, Liangliang
;
Xu, Chunxia
;
Wang, Ziying
;
Duan, Shuyi
;
Xu, Jinjin
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/04/10
Xian-Ling-Gu-Bao capsule
estrogens
glucuronidation
inhibitory effects
UDP-glucuronosyltransferase
Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
He, Yi-fei
;
Liu, Yin
;
Yu, Jing-hua
;
Cheng, Huan
;
Odilov, Abdullajon
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/08/16
TPN171
[C-14]TPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 798-808
作者:
Zheng, Yuandong
;
Zhang, Hua
;
Liu, Mengling
;
Li, Guangze
;
Ma, Sheng
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/08/16
Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin
期刊论文
OAI收割
SEPARATIONS, 2022, 卷号: 9, 期号: 5, 页码: 15
作者:
Jiang, Haodong
;
Liu, Huan
;
Hu, Pei
;
Chen, Shuoji
;
Ye, Yaqing
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/08/16
calycosin
first-pass effect
intestinal glucuronidation
liver distribution
metabolism
Absorption, metabolism, and excretion of [C-14]YY-20394, a highly selective PI3K-Delta inhibitor in humans
期刊论文
OAI收割
XENOBIOTICA, 2022, 页码: 11
作者:
Yu, Jinghua
;
Zhang, Hua
;
Zhang, Yifan
;
Zhan, Yan
;
Ma, Sheng
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/06/15
YY-20394
[C-14]YY-20394
mass balance
drug metabolism
pharmacokinetics
Quantification of the major circulating metabolite of BS1801, an ebselen analog, in human plasma
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 卷号: 212, 页码: 10
作者:
Tian, Qianqian
;
Jiang, Jinfang
;
Yin, Hanwei
;
Ma, Jiao
;
Deng, Guozhen
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/06/15
BS1801
Ebselen
Circulating metabolite
Human plasma
LC-MS/MS