中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页
机构
成果
学者
登录
注册
登陆
×
验证码:
换一张
忘记密码?
记住我
×
校外用户登录
CAS IR Grid
机构
上海药物研究所 [55]
海洋研究所 [4]
上海生物化学与细胞生... [4]
福建物质结构研究所 [3]
西北高原生物研究所 [2]
昆明植物研究所 [2]
更多
采集方式
OAI收割 [88]
内容类型
期刊论文 [85]
学位论文 [3]
发表日期
2024 [3]
2023 [4]
2022 [3]
2021 [7]
2020 [2]
2019 [2]
更多
学科主题
Chemistry [5]
Pharmacolo... [3]
Biochemist... [2]
Biochemist... [1]
Cell Biolo... [1]
Computer S... [1]
更多
筛选
浏览/检索结果:
共88条,第1-10条
帮助
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
提交时间升序
提交时间降序
作者升序
作者降序
题名升序
题名降序
发表日期升序
发表日期降序
GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states
期刊论文
OAI收割
BMC BIOINFORMATICS, 2024, 卷号: 25, 期号: 1, 页码: 16
作者:
Liu, Fan
;
Zhou, Han
;
Li, Xiaonong
;
Zhou, Liangliang
;
Yu, Chungong
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/12/06
G-protein coupled receptor
State-specific structure
Binding site
Key residue
Database
Structural insights into the molecular effects of the anthelmintics monepantel and betaine on the
Caenorhabditis elegans
acetylcholine receptor ACR-23
期刊论文
OAI收割
EMBO JOURNAL, 2024, 页码: 20
作者:
Liu, Fenglian
;
Li, Tianyu
;
Gong, Huihui
;
Tian, Fei
;
Bai, Yan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/08/22
Acetylcholine Receptor
Monepantel
Betaine
Anthelmintics
Cryo-EM Structure
A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 107, 页码: 19
作者:
Wang, Xiaoyan
;
Yun, Ying
;
Chen, Lili
;
Guo, Shimeng
;
Niu, Buying
  |  
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2024/07/12
Diabetes
GLP-1 receptor
Agonist
Structural optimization
Water molecule replacement
Structure activity relationship
Docking simulation
Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 17
作者:
Zhu, Yueyue
;
Liu, Bo
;
Chen, Zonglong
;
Wang, Xianyang
;
Wang, Yujie
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2023/12/08
Toll -like receptor 2/6 agonists
PamCS
Structure-activity relationship
Lipopeptide
Immunostimulants
Discovery of Potent and Selective CB2 Agonists Utilizing a Function-Based Computational Screening Protocol
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2023, 卷号: 14, 期号: 21, 页码: 3941-3958
作者:
Ge, Haixia
;
Ji, Beihong
;
Fang, Jiahui
;
Wang, Jiayang
;
Li, Jing
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2023/12/11
function-based ligand design
receptor-ligandbinding profile
CB1/CB2
structure-activityrelationship
Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes
期刊论文
OAI收割
JOURNAL OF STRUCTURAL BIOLOGY, 2023, 卷号: 215, 期号: 3, 页码: 9
作者:
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2023/10/17
SARS-CoV-2 virus
Receptor -binding domain
Nanobody
Crystal structure
Conservative binding epitope
Bi-paratopic nanobodies
Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16
作者:
Chen, Yun
;
Ning, Yi
;
Chen, Zhiwei
;
Xue, Yaping
;
Wu, Qingyun
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2023/10/17
Apoptosis
Diffuse large B-Cell lymphoma
Interleukin-1 receptor associated kinase 4
Structure-based drug design
2
3-Dihydrobenzofuran
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 11
作者:
Zhao, Li-hua
;
Yuan, Qing-ning
;
Dai, An-tao
;
He, Xin-heng
;
Chen, Chuan-wei
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2023/04/10
G protein- coupled receptors
parathyroid hormone
PTH-related peptide
PTH receptor-1
cryo-electron microscopy structure
osteoporosis
岩藻糖化糖胺聚糖 系统给药的毒性作用及其相关的血小板激活作用与机制
学位论文
OAI收割
: 中国科学院大学, 2022
作者:
林丽莎
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2024/05/14
岩藻糖化糖胺聚糖,毒性机制,血小板聚集,构效关系,血小板受体
Fucosylated glycosaminoglycan, Toxic effect, Platelet aggregation, Structure-activity relationship, Platelet receptor
Divergences of the RLR Gene Families across Lophotrochozoans: Domain Grafting, Exon-Intron Structure, Expression, and Positive Selection
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 卷号: 23, 期号: 7, 页码: 20
作者:
Yao, Shanshan
;
Chan, Jiulin
;
Xu, Yue
;
Wu, Shimei
;
Zhang, Linlin
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2022/07/18
RIG-I-like receptor
lophotrochozoan
innate immune
molecular evolution
gene expression
domain grafting
exon-intron structure
positive selection