中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页
机构
成果
学者
登录
注册
登陆
×
验证码:
换一张
忘记密码?
记住我
×
校外用户登录
CAS IR Grid
机构
上海药物研究所 [60]
过程工程研究所 [2]
大连化学物理研究所 [1]
武汉病毒研究所 [1]
昆明植物研究所 [1]
中国科学院大学 [1]
更多
采集方式
OAI收割 [64]
iSwitch采集 [2]
内容类型
期刊论文 [63]
学位论文 [2]
会议论文 [1]
发表日期
2023 [3]
2022 [4]
2021 [3]
2020 [4]
2018 [1]
2017 [1]
更多
学科主题
Biochemist... [2]
Chemistry [2]
Pharmacolo... [2]
Biochemica... [1]
Chemistry,... [1]
Psychiatry [1]
更多
筛选
浏览/检索结果:
共66条,第1-10条
帮助
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
提交时间升序
提交时间降序
发表日期升序
发表日期降序
题名升序
题名降序
作者升序
作者降序
Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20
作者:
Yang, Wenjiao
;
Gong, Xudong
;
Sun, Haiguo
;
Wu, Chunhui
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/03/06
CB2R agonist
5-HT1AR agonist
CB1R antagonist
Antidepressant
Anxiolytic
Recognition of methamphetamine and other amines by trace amine receptor TAAR1
期刊论文
OAI收割
NATURE, 2023, 卷号: 624, 期号: 7992, 页码: 663-+
作者:
Liu, Heng
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/03/25
Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) inverse agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 18
作者:
Lu, Lixue
;
Chen, Song
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/10/17
ROR gamma t
Triazines
Inverse agonist
Psoriasis
Autoimmune diseases
Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115213
作者:
Sun, Nannan
;
Yu, Mingcheng
;
Jiang, Zhengyuan
;
Yang, Feng
;
Lu, Lixue
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/03/27
ROR?t agonists
Carbazole carboxamide
Agonistic activity
Metabolic stability
Co-crystallization
Molecular docking
Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 241, 页码: 16
作者:
Shen, Ancheng
;
Li, Xiyuan
;
Zhang, Yan
;
Ma, Jing
;
Xiao, Ruoxuan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/04/10
Innate immunity
STING Agonists
Structural modification
Immuno-oncology
PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way
期刊论文
OAI收割
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 卷号: 10, 期号: 10, 页码: 15
作者:
Yu, Xiaolu
;
Long, Yiru
;
Chen, Binfan
;
Tong, Yongliang
;
Shan, Mengwen
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/12/13
PD-L1
TLR7
nanobody-drug-conjugate
cancer immunotherapy
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
Darbalaei, Sanaz
;
Chang, Ru-lue
;
Zhou, Qing-tong
;
Chen, Yan
;
Dai, An-tao
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/09/30
glucagon-like peptide-1 receptor
glucagon receptor
dual and triple agonist
cAMP
pERK1/2
unimolecular polypharmacology
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 16
作者:
Zhao, Fenghui
;
Zhou, Qingtong
;
Cong, Zhaotong
;
Hang, Kaini
;
Zou, Xinyu
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/06/15
GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Chen, Yan
;
Xu, Ying-na
;
Ye, Chen-yu
;
Feng, Wen-bo
;
Zhou, Qing-tong
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/06/15
NAFLD
NASH
GLP-1R
GLP-1 mimetics
dual agonists
triple agonists
GPCR
Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 8
作者:
Wang, Yu-zhe
;
Yang, De-hua
;
Wang, Ming-wei
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/11/04
glucagon-like peptide-1 receptor
glucose-dependent insulinotropic peptide receptor
peptide 19
LY3298176
heteromerization
type 2 diabetes