中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [21]
化学研究所 [6]
昆明植物研究所 [6]
大连化学物理研究所 [4]
近代物理研究所 [4]
新疆理化技术研究所 [3]
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OAI收割 [52]
内容类型
期刊论文 [46]
学位论文 [4]
会议论文 [2]
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2025 [1]
2024 [2]
2023 [3]
2022 [7]
2021 [2]
2020 [4]
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学科主题
Biochemist... [1]
Chemistry [1]
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Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 155, 页码: 15
作者:
Yu, Nai-Rong
;
Huang, Suling
;
Deng, Zhen-Tao
;
Wang, Jiayue
;
Shen, Yu
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/04/01
Non-alcoholic steatohepatitis (NASH)
Alisol B
Structural modification
Structure-activity relationship
HFD+CCl4-induced NASH mice model
Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation
期刊论文
OAI收割
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13
作者:
Feng, Dazhi
;
Liu, Bo
;
Chen, Zhiwei
;
Xu, Jinyi
;
Geng, Meiyu
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2024/02/27
HPK1 inhibitor
machine learning
virtual screening
free energy perturbation
structural modification
Learning Sequential and Structural Dependencies Between Nucleotides for RNA N6-Methyla-denosine Site Identification
期刊论文
OAI收割
IEEE/CAA Journal of Automatica Sinica, 2024, 卷号: 11, 期号: 10, 页码: 2123-2134
作者:
Guodong Li
;
Bowei Zhao
;
Xiaorui Su
;
Dongxu Li
;
Yue Yang
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/09/03
Cross-domain reconstruction
cross-species prediction
N6-methyladenosine (m6A) modification site
RNA sequence
sequential and structural dependencies
Heat sensitive E-helix cut ferritin nanocages for facile and high-efficiency loading of doxorubicin
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 卷号: 253
作者:
Xia, Haining
;
Xu, Huangtao
;
Wang, Jiarong
;
Wang, Changhao
;
Chen, Ruiguo
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2023/11/17
Ferritin nanocages
Drug loading
Structural modification
Thermal response
Ion-assisted
Discovery of diverse sesquiterpenoids from Magnolia grandiflora with cytotoxic activities by inducing cell apoptosis
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 106707
作者:
Xu,Shuangyu
;
Tang,Yunyan
;
Li,Yanan
;
Yang,Jue
;
Gu,Wei
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/07/22
Magnolia grandiflora
Sesquiterpenoids
Isolation and structural modification
Cytotoxic activity
Apoptosis
LACTONES
DERIVATIVES
LEAVES
AGENTS
Structurally modified Cyclovirobuxine-D Buxus alkaloids as effective analgesic agents through Cav3.2 T-Type calcium channel inhibition
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 135, 页码: 106493
作者:
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/07/22
Buxus alkaloid
Structural modification
T -type calcium channel
Analgesic activity
Docking analysis
Structure -activity relationship study
BUXOZINE-C
SEMPERVIRENS
RING
CONSTITUTION
Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 241, 页码: 16
作者:
Shen, Ancheng
;
Li, Xiyuan
;
Zhang, Yan
;
Ma, Jing
;
Xiao, Ruoxuan
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2023/04/10
Innate immunity
STING Agonists
Structural modification
Immuno-oncology
20-去氧巨大戟醇酯衍生物合成及其构效关系研究
学位论文
OAI收割
: 中国科学院大学, 2022
作者:
张翠珊
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/05/14
20-去氧巨大戟醇酯,自噬,结构修饰,构效关系
20-Deoxyingenane esters, Autophagy, Structural modification, SAR
海菜花化学成分研究和Telekin的结构改造
学位论文
OAI收割
: 中国科学院大学, 2022
作者:
曾政权
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/05/14
天然产物、海菜花、天名精、倍半萜内酯、结构修饰
Natural Products, Ottelia acuminata, Carpesium abrotanoides L., Sesquiterpene lactone, Structural modification
Design and semisynthesis of oleanolic acid derivatives as VEGF in- hibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs
期刊论文
OAI收割
CHINESE JOURNAL OF NATURAL MEDICINES, 2022, 卷号: 20, 期号: 3, 页码: 229-240
作者:
Meng Ning
;
Xie Hong-Xu
;
Hou Jia-Rong
;
Chen Yon-Bin
;
Wu Meng-Jun
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/06/15
Oleanolic acid
Structural modification
VEGF inhibitor
VEGFR2
Angiogenesis