中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [15]
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OAI收割 [15]
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期刊论文 [14]
会议论文 [1]
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2023 [1]
2021 [1]
2020 [4]
2018 [4]
2017 [1]
2014 [1]
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专题:上海药物研究所
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Discovery of new small molecule inhibitors of the BPTF bromodomain
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 134, 页码: 106453
作者:
Liang, Xiaochen
;
Cao, Yu
;
Duan, Zhe
;
Wang, Mingchen
;
Zhang, Naixia
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/27
BPTF bromodomain
BPTF inhibitors
HTRF
c-Myc
Design, Synthesis and SAR Studies of Novel and Potent Dipeptidyl Peptidase 4 Inhibitors
期刊论文
OAI收割
CHINESE JOURNAL OF CHEMISTRY, 2021, 卷号: 39, 期号: 1, 页码: 115-120
作者:
Luo, Na
;
Fang, Xiaoyu
;
Su, Mingbo
;
Zhang, Xinwen
;
Li, Dan
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/03/21
Type II diabetes
Dipeptidyl peptidase IV
Inhibitors
Molecular docking
Structure‐ activity relationship
Design, Synthesis, and Biological Activities of Novel Triazolothiadiazole Derivatives Linked with Amino Side Chain Containing Urea Group as DOT1L Inhibitors
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 8, 页码: 2450-2459
作者:
Liu Na
;
Guo Siqi
;
Liu Junfang
;
Chen Yantao
;
Xu Xiaoming
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
DOT1L inhibitor
triazolothiadiazole
triazolothiadiazine
nucleophilic substitution
Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13
作者:
Wang, Zheng
;
Li, Zeng-xia
;
Zhao, Wen-cao
;
Huang, Hong-bo
;
Wang, Jia-qi
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/12/24
grincamycin B
marine natural product
isocitrate dehydrogenase 1
apoptosis
ER stress
intracellular ROS
Zebrafish embryos
hematological malignancies
Structural Modifications of the Triazolo-thiadiazole Derivatives as DOT1L Inhibitors and Their Activities
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 5, 页码: 1345-1354
作者:
Xu Xiaoming
;
Guo Siqi
;
Zhang Jing
;
Chen Yantao
;
Kang Yaqing
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/12/24
DOT1L inhibitor
ttriazolo-thiadiazole
structural modification
hydrophobic substituent
structure-activity analysis
A Sphingosine-1-Phosphate Modulator Ameliorates Polycystic Kidney Disease in Han:SPRD Rats
期刊论文
OAI收割
AMERICAN JOURNAL OF NEPHROLOGY, 2020, 卷号: 51, 期号: 1, 页码: 1-10
作者:
Li, Xin
;
Wu, Ming
;
Chen, Limin
;
Lu, Junyan
;
Li, Guo
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
FTY720
Sphingosine-1-phosphate
Cordyceps sinensis
Autosomal dominant polycystic kidney disease
Inflammation
Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654
作者:
Zhang, Li
;
Chen, Yantao
;
Liu, Na
;
Li, Linjuan
;
Xiao, Senhao
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
Pyrimidylaminoquinoline
Nonnucleoside DOT1L inhibitors
Amino side chains
Mixed-linage leukemia
Histone lysine methyltransferase
Enhancement of Glucose Utilization by Loesenerine through AMPK Activation in Myotubes
期刊论文
OAI收割
CHEMICAL & PHARMACEUTICAL BULLETIN, 2018, 卷号: 66, 期号: 9, 页码: 885-886
作者:
Wang, Luo-Na
;
Jiang, Hao-Wen
;
Li, Jin-Long
;
Li, Jing-Ya
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
loesenerine
spermidine alkaloid
AMP-activated protein kinase activation
glucose uptake
Design, synthesis and biological evaluation of benzo[cd]indo1-2(1H)-ones derivatives as BRD4 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 264-273
作者:
Feng, Yuxin
;
Xiao, Senhao
;
Chen, Yantao
;
Jiang, Hao
;
Liu, Na
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
Benzo[cd]indol-2(1H)-one
Sulfonamide
BRD4 inhibitor
Bromodomain and extra-terminal domain
Acetyl-lysine binding pocket
Activation of AhR with nuclear IKK alpha regulates cancer stem-like properties in the occurrence of radioresistance
期刊论文
OAI收割
CELL DEATH & DISEASE, 2018, 卷号: 9
作者:
Yan, Bin
;
Liu, Shuang
;
Shi, Ying
;
Liu, Na
;
Chen, Ling
  |  
收藏
  |  
浏览/下载:108/0
  |  
提交时间:2019/01/08