机构

• 上海药物研究所 [51]
• 昆明植物研究所 [5]
• 武汉病毒研究所 [3]
• 中国科学院大学 [1]
• 自动化研究所 [1]
• 生态环境研究中心 [1]
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采集方式

• OAI收割 [59]
• iSwitch采集 [4]

内容类型

• 期刊论文 [62]
• 学位论文 [1]

发表日期

• 2018 [4]
• 2017 [1]
• 2016 [2]
• 2012 [5]
• 2010 [1]
• 2009 [3]
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学科主题

• Biochemist... [3]
• Neuroscien... [2]
• Pharmacolo... [2]
• Cell Biolo... [1]
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• Chemistry,... [1]
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筛选

浏览/检索结果: 共63条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Design, synthesis, in vitro evaluation of a new pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer's disease 期刊论文  OAI收割 JOURNAL OF HETEROCYCLIC CHEMISTRY, 2022, 页码: 16 作者:  Zeng, Yan;  Nie, Lifei;  Liu, Liu;  Niu, Chao;  Li, Yi   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/06/15 Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation 期刊论文  OAI收割 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 5, 页码: 521-530 作者:  Jiang, Cheng-Shi;  Ge, Yong-Xi;  Cheng, Zhi-Qiang;  Song, Jia-Li;  Wang, Yin-Yin   |  收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 AChE inhibitor  Pharmacophore model  Molecular docking  Anti-A aggregation  Neuroprotective activity   Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease 期刊论文  OAI收割 ACS chemical neuroscience, 2018 作者:  Wang, Huan;  Zhang, Haiyan   |  收藏  |  浏览/下载：56/0  |  提交时间：2019/01/08 Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors 期刊论文  OAI收割 Bioorganic chemistry, 2018, 卷号: 83, 页码: 277-288 作者:  Cheng, Zhi-Qiang;  Zhu, Kong-Kai;  Zhang, Juan;  Song, Jia-Li;  Muehlmann, Luis Alexandre   |  收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08 Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease 期刊论文  OAI收割 ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345 作者:  Mao, Fei;  Wang, Huan;  Ni, Wei;  Zheng, Xinyu;  Wang, Manjiong   |  收藏  |  浏览/下载：56/0  |  提交时间：2019/01/08 Alzheimer's disease  drug repositioning  dual-target inhibitor  AChE inhibition  PDE5 inhibition   Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 33-47 作者:  Xu, Yi-xiang   |  收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 Multifunctional agents  AChE inhibitors  MAO-B inhibitors  Metal chelating agents  Alzheimer's disease   An enantiomer-based virtual screening approach: Discovery of chiral organophosphates as acetyl cholinesterase inhibitors 期刊论文  OAI收割 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2017, 卷号: 138, 期号: 0, 页码: 215-222 作者:  Zhang, Aiqian;  Mu, Yunsong;  Wu, Fengchang   |  收藏  |  浏览/下载：27/0  |  提交时间：2018/07/26 Chiral Organophosphates  Enantioselectivity  In Vitro testIng  Molecular Docking  Virtual Screening   Rapid eye movement sleep behavior disorder in patients with probable Alzheimer's disease 期刊论文  OAI收割 Aging Clin Exp Res, 2016, 卷号: 28, 期号: 5, 页码: 951-7 作者:  Wang, P, Wing, Y. K, Xing, J, Liu, Y, Zhou, B, Zhang, Z, Yao, H, Guo, Y, Shang, Y, Zhang, X   |  收藏  |  浏览/下载：15/0  |  提交时间：2019/03/05 Aged,Aged, 80 and over,Alzheimer Disease/*complications,Animals,Cholinesterase Inhibitors/therapeutic use,Electromyography,Female,Humans,Male,Middle Aged,Polysomnography,Probability,REM Sleep BehaviorDisorder/*epidemiology,Sleep/physiology,Sleep, REM/*physiology,Alzheimer's disease,REM sleep behavior disorder,REM sleep without atonia,Video-polysomnography   The discovery of new acetylcholinesterase inhibitors derived from pharmacophore modeling, virtual screening, docking simulation and bioassays 期刊论文  OAI收割 MOLECULAR BIOSYSTEMS, 2016, 卷号: 12, 期号: 12, 页码: 3734-3742 作者:  Zhang, Yunqin;  Zhang, Shuqun;  Xu, Guowei;  Yan, Hui;  Pua, Yinglan 收藏  |  浏览/下载：29/0  |  提交时间：2017/02/14 Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of humanacetylcholinesterase and butyrylcholinesterase 期刊论文  OAI收割 Chemistry Central Journal, 2012, 卷号: 6, 期号: 1 作者:  Wang,Yue-Hu;  Wan,Qin-Li;  Gu,Cheng-Ding;  Luo,Huai-Rong;  Long,Chun-Lin   |  收藏  |  浏览/下载：9/0  |  提交时间：2018/09/27 Amaryllidaceae alkaloids  Lycorine  Acetylcholinesterase  Butyrylcholinesterase