中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [16]
大连化学物理研究所 [5]
广州生物医药与健康研... [2]
西双版纳热带植物园 [1]
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期刊论文 [28]
会议论文 [1]
学位论文 [1]
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2023 [2]
2020 [1]
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Rhodium(III)-Catalyzed C-H/O2 Dual Activation and Macrocyclization: Synthesis and Evaluation of Pyrido[2,1-a]isoindole Grafted Macrocyclic Inhibitors for Influenza H1N1
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 卷号: 62, 期号: 15
作者:
Song, Bichao
;
Guo, Xueying
;
Yang, Li
;
Yu, Haiyue
;
Zong, Xinlei
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/03/27
C-H Activation
Macrocyclization
Multicomponent Coupling
O-2 Activation
Rh Catalysis
Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design
期刊论文
OAI收割
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2023, 卷号: 89, 期号: 3
作者:
Gao, Qilin
;
Ma, Bingbing
;
Wang, Qianwen
;
Zhang, Hao
;
Fushinobu, Shinya
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/03/27
P450
testosterone
androstenedione
crystal structure
rational design
Computational Biotransformation Profile of Emerging Phenolic Pollutants by Cytochromes P450: Phenol-Coupling Mechanism
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 卷号: 54, 期号: 5, 页码: 2902-2912
作者:
Guo, Fangjie
;
Chai, Lihong
;
Zhang, Shubin
;
Yu, Haiying
;
Liu, Weiping
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/03/24
Differences in the In Vivo and In Vitro Metabolism of Imrecoxib in Humans: Formation of the Rate-Limiting Aldehyde Intermediate
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2018, 卷号: 46, 期号: 9, 页码: 1320-1328
作者:
Hou, Xiangyu
;
Zhou, Jialan
;
Yu, Songda
;
Zhou, Lei
;
Zhang, Yifan
  |  
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2019/01/08
Reactivity Patterns of (Protonated) CompoundII and CompoundI of Cytochrome P450: Which is the Better Oxidant?
期刊论文
OAI收割
Chemistry - A European Journal, 2017, 卷号: 23, 期号: 26, 页码: 6406-6418
作者:
Li, Xiao-Xi
;
Verknica Postils
;
Sun, Wei
;
AbayomiS.Faponle
;
Miquel Sola
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2017/07/10
cytochrome P450
density functional calculations
electronic structure
hydroxylation
oxidation
Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones
期刊论文
OAI收割
NEW PHYTOLOGIST, 2016, 卷号: 210, 期号: 2, 页码: 525-534
作者:
Cui, Guanghong
;
Guo, Juan
;
Ma, Xiaohui
;
Cai, Yuan
;
Ma, Ying
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/06/20
Cytochrome P450 (Cyp) Monooxygenases
Diterpenoid Biosynthesis
Enzymatic Promiscuity
Metabolic Pathways
Salvia Miltiorrhiza Bunge
Synthetic Biology
Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity
期刊论文
OAI收割
Chemico-biological interactions, 2016, 卷号: 243, 页码: 119-26
作者:
Yang, Mengbi
;
Ruan, Jianqing
;
Fu, Peter P
;
Lin, Ge
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions
期刊论文
OAI收割
CURRENT ORGANIC CHEMISTRY, 2016, 卷号: 20, 期号: 17, 页码: 1827-1834
作者:
Gao, LQ
;
Chen J(陈俊)
;
Hu Y(胡毅)
;
Chen, J
;
Hu, Y
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2017/07/24
Bupropion
drug-drug interactions (DDIs)
gemfibrozil
metabolites
pharmacodynamics
pharmacokinetics
Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 卷号: 16, 期号: 7, 页码: 16454-16468
作者:
Wang, Ke
;
Feng, Chenchen
;
Li, Chenggang
;
Yao, Jun
;
Xie, Xiaofeng
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
aristolochic acid
kidney injury
baicalin
aromatic hydrocarbon receptor
CYP1A
Metabolic profiling of praziquantel enantiomers
期刊论文
OAI收割
biochemical pharmacology, 2014, 卷号: 90, 期号: 2, 页码: 166-178
作者:
Wang, Haina
;
Fang, Zhong-Ze
;
Zheng, Yang
;
Zhou, Kun
;
Hu, Changyan
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2015/11/17
Cytochromes P450
Enantioselective metabolism
In silica metabolomics
Praziquantel