中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [119]
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期刊论文 [158]
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Tora3D: an autoregressive torsion angle prediction model for molecular 3D conformation generation
期刊论文
OAI收割
JOURNAL OF CHEMINFORMATICS, 2023, 卷号: 15, 期号: 1, 页码: 14
作者:
Zhang, Zimei
;
Wang, Gang
;
Li, Rui
;
Ni, Lin
;
Zhang, RunZe
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/10/17
Conformations generation
Autoregressive
Transformer
Deep learning
Small molecules
Covalent Binding Mechanism of Furmonertinib and Osimertinib With Human Serum AlbuminS
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2023, 卷号: 51, 期号: 1, 页码: 8-16
作者:
Wu, Yali
;
Chen, Lili
;
Chen, Jian
;
Xue, Hao
;
He, Qingfeng
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/03/27
Changes in Disposition of Ezetimibe and Its Active Metabolites Induced by Impaired Hepatic Function: The Influence of Enzyme and Transporter Activities
期刊论文
OAI收割
PHARMACEUTICS, 2022, 卷号: 14, 期号: 12, 页码: 22
作者:
Xie, Ningjie
;
Wang, Hong
;
Qin, Hua
;
Guo, Zitao
;
Xue, Hao
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/04/10
hepatic impairment
ezetimibe
active metabolites
phase II enzymes
transporters
first-pass metabolism
inhibitory bile acids
Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 12, 页码: 3080-3095
作者:
Li, Chuan
;
Jia, Wei-wei
;
Yang, Jun-ling
;
Cheng, Chen
;
Olaleye, Olajide E.
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/03/21
Chinese herbal medicine
pharmacokinetics
multi-compound pharmacokinetic research
drug-combination pharmacokinetic research
pharmacokinetic compatibility
Mesenchymal Stem Cell Fates in Murine Acute Liver Injury and Chronic Liver Fibrosis Induced by Carbon Tetrachloride
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 10, 页码: 1352-1360
作者:
Ma, Chenhui
;
Han, Li
;
Wu, Jiajun
;
Tang, Feng
;
Deng, Qiangqiang
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/04/10
Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 809-818
作者:
Guo, Zitao
;
Liu, Mengling
;
Meng, Jian
;
Xue, Yaru
;
Huang, Qi
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/08/16
Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 798-808
作者:
Zheng, Yuandong
;
Zhang, Hua
;
Liu, Mengling
;
Li, Guangze
;
Ma, Sheng
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收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/08/16
Molecular Basis Underlying Hepatobiliary and Renal Excretion of Phenolic Acids of Salvia miltiorrhiza Roots (Danshen)
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 13
作者:
Lu, Jun-Lan
;
Zeng, Xue-Shan
;
Zhou, Xin
;
Yang, Jun-Ling
;
Ren, Ling-Ling
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/08/16
Danshen
Salvia miltiorrhiza
phenolic acid
hepatic transporter
renal transporter
Absorption, metabolism, and excretion of [C-14]YY-20394, a highly selective PI3K-Delta inhibitor in humans
期刊论文
OAI收割
XENOBIOTICA, 2022, 页码: 11
作者:
Yu, Jinghua
;
Zhang, Hua
;
Zhang, Yifan
;
Zhan, Yan
;
Ma, Sheng
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/06/15
YY-20394
[C-14]YY-20394
mass balance
drug metabolism
pharmacokinetics
FEK self-assembled peptide hydrogels facilitate primary hepatocytes culture and pharmacokinetics screening
期刊论文
OAI收割
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2022, 页码: 13
作者:
He, Ting
;
Qiao, Shida
;
Ma, Chen
;
Peng, Zhaoliang
;
Wu, Zhitao
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/06/15
biliary excretion index
FEFEFKFK self-assembling peptide hydrogel
metabolic enzymes
rat primary hepatocytes
sandwich culture
transporters