中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海生物化学与细胞生... [6]
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Design and Synthesis Studies of α-Methylene-γ-butyrolactones Antagonists of GPR52
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2023, 卷号: 43, 期号: 11, 页码: 3916-3929
作者:
Shen, Donghang
;
Li, Xin
;
Guo, Shimeng
;
Xie, Xin
;
Nan, Fajun
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/02/27
Huntingdon's disease
G protein-coupled receptor
GPR52
alpha-methylene-gamma-butyrolactones
antagonist
GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 941-957
作者:
Wang, Congcong
;
Zhang, Yu-Fang
;
Guo, Shimeng
;
Zhao, Quan
;
Zeng, Yanping
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/05/24
Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 卷号: 42, 期号: 10, 页码: 1556-1566
作者:
Li, Xiao-jing
;
Zhang, Yuan-yuan
;
Fu, Yu-hua
;
Zhang, Hao
;
Li, He-xuan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/21
Huntington disease
mutant huntingtin protein
gossypol acetate
VCP
LC3
autophagic degradation
drug reposition
应用鞣花酸治疗亨廷顿舞蹈病转基因小鼠的研究
学位论文
OAI收割
: 中国科学院大学, 2020
作者:
孙勋
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/09/07
亨廷顿舞蹈病,鞣花酸,神经炎症,寡聚体,自噬
Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein
期刊论文
OAI收割
FOOD & FUNCTION, 2020, 卷号: 11, 期号: 2, 页码: 1334-1348
作者:
Sun, Xun
;
Zhu, Jie
;
Sun, Xiao-ying
;
Ji, Mei
;
Yu, Xiao-lin
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/05/06
Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-kappa B signaling pathway
期刊论文
OAI收割
BRAIN RESEARCH, 2018, 卷号: 1697, 页码: 21-33
作者:
Liu, Shu-ying
;
Yu, Xiao-lin
;
Zhu, Jie
;
Liu, Xiang-meng
;
Zhang, Yue
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2018/10/11
Huntington's Disease
Polyglutamine
Intravenous Immunoglobulin
Huntingtin Protein
PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin
期刊论文
OAI收割
FASEB JOURNAL, 2018, 卷号: 32, 期号: 6, 页码: 2923-2933
作者:
Yang, Hui
;
Yue, Hong-Wei
;
He, Wen-Tian
;
Hong, Jun-Ye
;
Jiang, Lei-Lei
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/04/28
Protein-quality Control
Group-c Protein
Polyglutamine Disease
Alpha-synuclein
Neurodegenerative Diseases
Parkinsons-disease
Nuclear Inclusions
Nucleocytoplasmic Transport
Deubiquitinating Function
Cytoplasmic Inclusions
A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses
期刊论文
OAI收割
SCIENTIFIC REPORTS, 2016, 卷号: 6, 期号: NOV, 页码: 36631
作者:
Zha, Jun
;
Liu, Xiang-meng
;
Zhu, Jie
;
Liu, Shu-ying
;
Lu, Shuai
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2016/12/26
Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: Implication in a loss-of-function pathology
期刊论文
OAI收割
SCIENTIFIC REPORTS, 2014, 卷号: 4, 期号: 1, 页码: 6410-6410
作者:
Yang, H
;
Li, JJ
;
Liu, S
;
Zhao, J
;
Jiang, YJ
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2015/07/22
Autoinhibitory Structure of the WW Domain of HYPB/SETD2 Regulates Its Interaction with the Proline-Rich Region of Huntingtin
期刊论文
OAI收割
STRUCTURE, 2014, 卷号: 22, 期号: 3, 页码: 378-386
作者:
Gao, YG
;
Yang, H
;
Zhao, J
;
Jiang, YJ
;
Hu, HY
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2015/07/22