中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [58]
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期刊论文 [132]
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Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:
Liu, Yingqiang
;
Zhan, Zhengsheng
;
Kang, Zhuang
;
Li, Mengyuan
;
Lv, Yongcong
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/01/26
Small molecule inhibitor
Tumor microenvironment
Immune-checkpoint
immune-deficient mouse models
including temozolomide (TMZ) insensitive tumors. Notably
Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 23, 页码: 16201-16221
作者:
Xie, Chenghu
;
Liu, Bo
;
Song, Zilan
;
Yang, Ye
;
Dai, Mengdi
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/02/27
AhR-STAT3-HO-1/COX-2 signalling pathway may restrict ferroptosis and improve hMSC accumulation and efficacy in mouse liver
期刊论文
OAI收割
BRITISH JOURNAL OF PHARMACOLOGY, 2023, 页码: 17
作者:
Han, Li
;
Ma, Chenhui
;
Wu, Zhitao
;
Xu, Huiming
;
Li, Hai
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/08
aryl hydrocarbon receptor
ferroptosis
iron
ischaemia/reperfusion liver injury
liver disease
mesenchymal stem cells
Breaking Tumor Immunosuppressive Network by Regulating Multiple Nodes with Triadic Drug Delivery Nanoparticles
期刊论文
OAI收割
ACS NANO, 2023, 卷号: 17, 期号: 18, 页码: 17826-17844
作者:
Yan, Wenlu
;
Li, Yu
;
Zou, Yiting
;
Zhu, Runqi
;
Wu, Ting
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/08
triple-negative breast cancer
antitumor immunity
tumor-associated macrophages
myeloid-derived suppressorcells
immune network
nanoparticle
Treating relapsed/refractory mature T- and NK-cell neoplasms with tislelizumab: a multicenter open-label phase 2 study
期刊论文
OAI收割
BLOOD ADVANCES, 2023, 卷号: 7
作者:
Bachy, Emmanuel
;
Savage, Kerry J.
;
Huang, Huiqiang
;
Kwong, Yok-Lam
;
Gritti, Giuseppe
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/11/10
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 6, 页码: 1122-1134
作者:
Wang, Qing
;
Yao, Sheng
;
Yang, Ze-xian
;
Zhou, Chen
;
Zhang, Yu
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/03/27
Parkinson's disease
alpha-synuclein aggregation
protein-protein interaction
03A10
MPTP/p model
enema inoculation model
Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression
期刊论文
OAI收割
JOURNAL OF CLINICAL INVESTIGATION, 2023, 卷号: 133, 期号: 9, 页码: 12
作者:
Wang, Xiaobo
;
Huang, Jing
;
Liu, Fenglin
;
Yu, Qian
;
Wang, Ruina
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/10/17
Combined Use of Immune Checkpoint Inhibitors and Phytochemicals as a Novel Therapeutic Strategy against Cancer
期刊论文
OAI收割
JOURNAL OF CANCER, 2023, 卷号: 14, 期号: 12, 页码: 2315-2328
作者:
Luo, LingJie
;
Lin, Caiji
;
Wang, Pengfei
;
Cao, Danli
;
Lin, Yiru
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
Immune checkpoint inhibitor
Phytochemicals
Combination therapy
Immune-related adverse events
Predictive biomarker
Gut microbiota
In-situ clickable prodrug nanoplatform locally activates T lymphocytes to potentiate cancer immunotherapy
期刊论文
OAI收割
NANO TODAY, 2022, 卷号: 47, 页码: 11
作者:
Hou, Bo
;
Ye, Jiayi
;
Li, Junhao
;
Xu, Zhiai
;
Yu, Haijun
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2023/04/10
Immune-excluded tumor
Extracellular matrix
In-situ click reaction
Prodrug nanoparticles
Immune resistance
Redox Dyshomeostasis with Dual Stimuli-Activatable Dihydroartemisinin Nanoparticles to Potentiate Ferroptotic Therapy of Pancreatic Cancer
期刊论文
OAI收割
SMALL METHODS, 2022, 页码: 13
作者:
Wang, Yingjie
;
Chen, Fangmin
;
Zhou, Huiling
;
Huang, Lujia
;
Ye, Jiayi
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/04/10
combinatory therapy
dual stimuli-responsive
ferroptosis
immunotherapy
pancreatic cancer