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上海药物研究所 [47]
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Chemical Inhibitors Targeting the Oncogenic m
6
A Modifying Proteins
期刊论文
OAI收割
ACCOUNTS OF CHEMICAL RESEARCH, 2023, 卷号: 56, 期号: 21, 页码: 3010-3022
作者:
Huang, Yue
;
Xia, Wenyang
;
Dong, Ze
;
Yang, Cai-Guang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/11
Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 138, 页码: 22
作者:
Wang, Hanlin
;
Wu, Zhaoxiao
;
Cao, Yu
;
Gao, Lixin
;
Shao, Jiaan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/10/17
Metabolic stability
Four-membered heterocycles
Proteasome inhibitors
Multiple myeloma
Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 18
作者:
Ren, Pengxuan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/10/17
Structure-based discovery of potent USP28 inhibitors derived from Vismodegib
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15
作者:
Zhou, Di
;
Xu, Zhuo
;
Huang, Yaodong
;
Wang, Hui
;
Zhu, Xiaoli
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/10/17
USP28
Structure-based
Vismodegib derivatives
Structure-activity relationships
c-Myc
Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2
期刊论文
OAI收割
European journal of medicinal chemistry, 2023, 卷号: 249, 页码: 115129
作者:
Ren, Pengxuan
;
Yu, Changyue
;
Zhang, Ruxue
;
Nie, Tianqing
;
Hu, Qiaoyu
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/26
Conjugation site characterization of antibody-drug conjugates using electron-transfer/higher-energy collision dissociation (EThcD)
期刊论文
OAI收割
ANALYTICA CHIMICA ACTA, 2023, 卷号: 1251, 页码: 7
作者:
Song, Yuanli
;
Gao, Jing
;
Meng, Qian
;
Tang, Feng
;
Wang, Yuqiu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
Antibody -drug conjugates
EThcD
Conjugation site
Peptide mapping
Quality control
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors
期刊论文
OAI收割
PROTEIN & CELL, 2023, 卷号: 14, 期号: 1, 页码: 17-27
作者:
Zang, Yi
;
Su, Mingbo
;
Wang, Qingxing
;
Cheng, Xi
;
Zhang, Wenru
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/03/27
high-throughput screening
SARS
CoV-2
main
papain-like
proteases
Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 11
作者:
Wang, Ruyu
;
Zhai, Guanglei
;
Zhu, Guanghao
;
Wang, Mengge
;
Gong, Xiaoyi
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/04/10
SARS-CoV-23CLpro
Thonzonium bromide
Mechanism of action
Broad-spectrum inhibitor
A functional metagenomics study of soil carbon and nitrogen degradation networks and limiting factors on the Tibetan plateau
期刊论文
OAI收割
FRONTIERS IN MICROBIOLOGY, 2023, 卷号: 14
作者:
Yang, Chong
;
Zhang, Hong
;
Zhao, Xinquan
;
Liu, Pan
;
Wang, Lushan
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2023/12/01
Complexation of multiple mineral elements by fermentation and its application in laying hens
期刊论文
OAI收割
FRONTIERS IN NUTRITION, 2022, 卷号: 9, 页码: 15
作者:
Chen, Huayou
;
Heng, Xinyu
;
Li, Keyi
;
Wang, Zhen
;
Ni, Zhong
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/02/24
mineral element complex
laying hen
synergistic fermentation
bean dregs
soybean meal
mineral element absorption