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	D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy 期刊论文 OAI收割 AGING-US, 2019, 卷号: 11, 期号: 14, 页码: 4943-4969 作者: Yu, Lexiang; Chen, Yao; Xu, Yong; He, Tao; Wei, Yan \| 收藏 \| 浏览/下载：55/0 \| 提交时间：2019/10/25 D-ribose benfotiamine (BTMP) cognitive impairment type 1 diabetic encephalopathy type 1 diabetes mellitus (T1DM) diabetic encephalopathy
	人工胰脏中血糖预测模型的关键问题研究学位论文 OAI收割博士: 中国科学院大学, 2015 作者: 李鹏收藏 \| 浏览/下载：76/0 \| 提交时间：2016/04/11 人工胰脏一型糖尿病数据驱动时间序列模型葡萄糖-胰岛素生理模型模型降阶硬件实现
	Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study 期刊论文 OAI收割 JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2015, 卷号: 35, 期号: 11, 页码: 1738-1745 作者: Zhang, Hui; Huang, Mingming; Gao, Lifeng; Lei, Hao 收藏 \| 浏览/下载：23/0 \| 提交时间：2015/12/22 animal modelsbrain imaging diabetes hyperglycemia MR spectroscopy
	Adjustment of basal insulin infusion rate in T1DM by hybrid PSO 期刊论文 OAI收割 SOFT COMPUTING, 2015, 卷号: 19, 期号: 7, 页码: 1921-1937 作者: Lou, Zhijiang; Liu, Bo; Xie, Hongzhi; Wang, Youqing \| 收藏 \| 浏览/下载：13/0 \| 提交时间：2018/07/30 Particle swarm optimization (PSO) Glycemic control Basal insulin infusion rate optimization Type 1 diabetes mellitus
	PID control of glucose concentration in subjects with type 1 diabetes based on a simplified model: An in silico trial (EI CONFERENCE) 会议论文 OAI收割 10th World Congress on Intelligent Control and Automation, WCICA 2012, July 6, 2012 - July 8, 2012, Beijing, China 作者: Yu L. 收藏 \| 浏览/下载：15/0 \| 提交时间：2013/03/25 An artificial pancreas system (APS) mimics the function of a real pancreas through monitoring a diabetic's blood glucose and administering the right dose of insulin via an automatic control loop. It is hailed as a promising cure of diabetes though this technology is still years away from commercial use due to a few technological bottlenecks. The simulation model of insulin-glucose metabolism of type 1 diabetes mellitus (T1DM) is an essential part of APS. In order to simplify the parameter identification task so that the model can be implemented electronically with ease this paper presents a simplified model based on Routh approximation model reduction method. The results show that the approximation error between the simplified model and the original model is so small that can be neglected. Based on the simplified model a PID controller is designed to maintain normoglycemia (90mg/dl) in subjects with T1DM. The in silico simulation results show that the glucose concentration is controlled well the risk of hyperglycemia and hypoglycemia is reduced a lot. This suggests that the simplified model describes the insulin-glucose metabolism process accurately and the PID control algorithm is well-suitable to guide the further development of an APS. 2012 IEEE.