机构

• 上海药物研究所 [141]

采集方式

• OAI收割 [141]

内容类型

• 期刊论文 [125]
• 学位论文 [12]
• 会议论文 [4]

发表日期

• 2023 [6]
• 2022 [8]
• 2021 [5]
• 2020 [6]
• 2019 [9]
• 2018 [8]
• 更多

学科主题

• Endocrinol... [1]
• Oncology [1]
• Urology & ... [1]

筛选

浏览/检索结果: 共141条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/02/19 Berberine derivative DCZ0358 induce oxidative damage by ROS-mediated JNK signaling in DLBCL cells 期刊论文  OAI收割 INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 卷号: 125, 页码: 15 作者:  Feng, Qilin;  Hu, Ke;  Hu, Huifang;  Lu, Yumeng;  Zhang, Hui   |  收藏  |  浏览/下载：24/0  |  提交时间：2024/01/16 DLBCL  ROS  DNA damage  JNK  Mitochondrial dysfunction   Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 23 作者:  Li, Xuemei   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/10/17 LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells 期刊论文  OAI收割 MOLECULAR ONCOLOGY, 2023, 卷号: 17, 期号: 8, 页码: 1678-1691 作者:  Xu, Beihui;  Li, Qi;  Zhang, Jianjun;  Chen, Fuxiang   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/03/27 Ajuba  apoptosis  chemoresistance  colorectal cancer  p53   Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, 页码: 11 作者:  Cai, Haiyan;  Wang, Yingying;  Zhang, Jing;  Wei, Zhenquan;  Yan, Teng   |  收藏  |  浏览/下载：16/0  |  提交时间：2023/10/17 Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1 期刊论文  OAI收割 Signal Transduction and Targeted Therapy, 2023, 卷号: 8, 期号: 3, 页码: 1159-1174 作者:  Xu, Heng;  Zhao, Hongfang;  Ding, Chunyong;  Jiang, Defang;  Zhao, Zijie   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/03/27 Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia 期刊论文  OAI收割 LEUKEMIA, 2022, 页码: 11 作者:  Jiang, Kailong;  Li, Xuemei;  Wang, Chang;  Hu, Xiaobei;  Wang, Peipei   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/04/10 Discovery of a Potent and Selective Degrader for USP7 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 卷号: 61, 期号: 33, 页码: e202204395 作者:  Pei, Yuan;  Fu, Jingfeng;  Shi, Yunkai;  Zhang, Mengmeng;  Luo, Guanghao   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/03/21 Apoptotic Pathway  Mutant p53  p53 Mutant Cancer Cells  PROTAC  USP7 Degrader   Phosphoproteomics Reveals the AMPK Substrate Network in Response to DNA Damage and Histone Acetylation 期刊论文  OAI收割 GENOMICS PROTEOMICS & BIOINFORMATICS, 2022, 卷号: 20, 期号: 4, 页码: 597-613 作者:  Jiang, Yuejing;  Cong, Xiaoji;  Jiang, Shangwen;  Dong, Ying;  Zhao, Lei   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/04/10 AMPK  Phosphoproteomics  Histone modification  DNA damage  Apoptosis   A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate 期刊论文  OAI收割 MOLECULES, 2022, 卷号: 27, 期号: 9, 页码: 18 作者:  Yu, Nian-Da;  Wang, Bing;  Li, Xin-Zhu;  Han, Hao-Zhen;  Liu, Dongxiang   |  收藏  |  浏览/下载：21/0  |  提交时间：2022/08/16 SIRT1  activator  covalent bond  2 '-O-acetyl-ADP-ribose  deacetylase