中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [15]
采集方式
OAI收割 [15]
内容类型
期刊论文 [15]
发表日期
2024 [1]
2021 [1]
2020 [4]
2019 [2]
2016 [3]
2012 [1]
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专题:上海药物研究所
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Ent-labdane-type diterpene glycosides obtained from
Rubus
chingii
Hu and their inhibitory effects on PDE5A activity
期刊论文
OAI收割
FITOTERAPIA, 2024, 卷号: 173, 页码: 14
作者:
Yu, Jun-dong
;
Wang, Jing-Yi
;
Liu, Jia-yuan
;
Xu, Ye-chun
;
Zhang, Xue
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/02/27
diterpene glycosides
Rubus Chingii Hu
PDE5A inhibitory activity
ent-labdane
A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia
期刊论文
OAI收割
Alzheimer's Research & Therapy, 2021, 卷号: 13, 期号: 1
作者:
Xiao,Shifu
;
Chan,Piu
;
Wang,Tao
;
Hong,Zhen
;
Wang,Shuzhen
  |  
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2021/05/24
Sodium oligomannate
Efficacy
Safety
Alzheimer’s disease
Clinical trial
Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13
作者:
Wang, Zheng
;
Li, Zeng-xia
;
Zhao, Wen-cao
;
Huang, Hong-bo
;
Wang, Jia-qi
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2020/12/24
grincamycin B
marine natural product
isocitrate dehydrogenase 1
apoptosis
ER stress
intracellular ROS
Zebrafish embryos
hematological malignancies
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Su, Hai-xia
;
Yao, Sheng
;
Zhao, Wen-feng
;
Li, Min-jun
;
Liu, Jia
  |  
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2020/12/24
SARS-CoV-2
3CL protease
traditional Chinese medicines
Shuanghuanglian oral liquid
baicalin
baicalein
Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma
期刊论文
OAI收割
JOURNAL OF HEPATOLOGY, 2020, 卷号: 72, 期号: 5, 页码: 896-908
作者:
Dong, Liang-qing
;
Peng, Li-hua
;
Ma, Li-jie
;
Liu, Dong-bing
;
Zhang, Shu
  |  
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2020/07/01
Hepatocellular carcinoma
Tumor heterogeneity
Tumor microenvironment
Immunoediting
Neoantigen
BRD4 as a therapeutic target for nonfunctioning and growth hormone pituitary adenoma
期刊论文
OAI收割
NEURO-ONCOLOGY, 2020, 卷号: 22, 期号: 8, 页码: 1114-1125
作者:
Shi, Chengzhang
;
Ye, Zhao
;
Han, Jie
;
Ye, Xiaoqing
;
Lu, Wenchao
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/03/21
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15
作者:
Lu, Wenchao
;
Wang, Jun
;
Li, Yong
;
Tao, Hongru
;
Xiong, Huan
  |  
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2020/07/01
Hippo pathway
TEAD transcription factor
Covalent inhibitor
Palmitoylation inhibitor
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1193-1204
作者:
Zhou, Ting-ting
;
Zhao, Tong
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
type 2 diabetes mellitus
hepatic gluconeogenesis
AMPK signaling pathway
(E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)
4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)
prodrug
Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2016, 卷号: 6, 期号: 1, 页码: 32-45
作者:
Zhou, Yu
;
Liu, Jun
;
Zheng, Mingyue
;
Zheng, Shuli
;
Jiang, Chunyi
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
5-Lipoxygenase
5-LOX inhibitors
Pyrazole derivatives
Leukotrienes-related diseases
In vivo
Benzo-fuse heterocyle
Ischemic incults
Brain inflammation
structuraloptimizationandbiologicalevaluationofl5disubstitutedpyrazole3carboxaminesaspotentinhibitorsofhuman5lipoxygenase
期刊论文
OAI收割
actapharmaceuticasinicab, 2016, 卷号: 6, 期号: 1, 页码: 32
作者:
Zhou Yu
;
Liu Jun
;
Zheng Mingyue
;
Zheng Shuli
;
Jiang Chunyi
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
5-Lipoxygenase
5-LOX inhibitors
Pyrazole derivatives
Leukotrienes-related diseases
In vivo
Benzo-fused heterocycle
Ischemic incults
Brain inflammation