中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [48]
采集方式
OAI收割 [48]
内容类型
期刊论文 [47]
会议论文 [1]
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2024 [1]
2023 [5]
2022 [4]
2021 [3]
2020 [3]
2019 [9]
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专题:上海药物研究所
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Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1079-1092
作者:
Qin, Shaozhao
;
Feng, Lijian
;
Zhao, Qingyi
;
Yan, Ziqin
;
Lyu, Xilin
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/02/27
Combination of irinotecan silicasome nanoparticles with radiation therapy sensitizes immunotherapy by modulating the activation of the cGAS/STING pathway for colorectal cancer
期刊论文
OAI收割
MATERIALS TODAY BIO, 2023, 卷号: 23, 页码: 16
作者:
Wang, Lu
;
Zhang, Tianyu
;
Zheng, Yile
;
Li, Yuting
;
Tang, Xiyuan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/11
ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA-Encoded Libraries
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 卷号: 145, 期号: 46, 页码: 25283-25292
作者:
Jiang, Lulu
;
Liu, Sixiu
;
Jia, Xinglong
;
Gong, Qinting
;
Wen, Xin
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/01/16
Discovery, SAR Study of GST Inhibitors from a Novel Quinazolin-4(1H)-one Focused DNA-Encoded Library
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 15
作者:
Wen, Xin
;
Zhang, Minmin
;
Duan, Zhiqiang
;
Suo, Yanrui
;
Lu, Weiwei
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2023/10/17
Structure-based discovery of potent USP28 inhibitors derived from Vismodegib
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15
作者:
Zhou, Di
;
Xu, Zhuo
;
Huang, Yaodong
;
Wang, Hui
;
Zhu, Xiaoli
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/10/17
USP28
Structure-based
Vismodegib derivatives
Structure-activity relationships
c-Myc
Fructose-1,6-bisphosphatase 1 dephosphorylates I kappa B alpha and suppresses colorectal tumorigenesis
期刊论文
OAI收割
CELL RESEARCH, 2023, 页码: 13
作者:
Zhu, Wencheng
;
Chu, Huiying
;
Zhang, Yajuan
;
Luo, Tianhang
;
Yu, Hua
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/04/10
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal
期刊论文
OAI收割
CELL STEM CELL, 2022, 卷号: 29, 期号: 9, 页码: 1366-+
作者:
Chen, Li
;
Jiao, Tingying
;
Liu, Weiwei
;
Luo, Yuhong
;
Wang, Jue
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/04/10
Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2022, 页码: 8
作者:
Li, Linjie
;
Su, Mingbo
;
Lu, Weiwei
;
Song, Hongzhi
;
Liu, Jiaxiang
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/09/30
DNA encoded library
covalent library
library design
covalent inhibitors
Systematic Qualitative and Quantitative Analyses of Wenxin Granule via Ultra-High Performance Liquid Chromatography Coupled with Ion Mobility Quadrupole Time-of-Flight Mass Spectrometry and Triple Quadrupole-Linear Ion Trap Mass Spectrometry
期刊论文
OAI收割
MOLECULES, 2022, 卷号: 27, 期号: 11, 页码: 21
作者:
Mi, Yueguang
;
Hu, Wandi
;
Li, Weiwei
;
Wan, Shiyu
;
Xu, Xiaoyan
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/08/16
Wenxin granule
multicomponent characterization
HDMSE-HDDDA
UHPLC-sMRM
quality evaluation
The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 3, 页码: 1460-1472
作者:
Li, Jingyi
;
Zhang, Yaqi
;
Yu, Miaorong
;
Wang, Aohua
;
Qiu, Yu
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2022/06/15
Ligand-modified nanoparticles
Transporter
Proton-coupled folate transporter
Expression level
Endocytosis
Intracellular trafficking
Diabetes
Oral insulin delivery