中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [23]
重庆绿色智能技术研究... [1]
近代物理研究所 [1]
采集方式
OAI收割 [25]
内容类型
期刊论文 [25]
发表日期
2022 [25]
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发表日期:2022
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Fused-ring alpha-pyrones from intramolecular C-H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 244, 页码: 11
作者:
Mao, Yingle
;
Li, Jiaomeng
;
Tang, Chunping
;
Ma, Biao
;
Xu, Zhijian
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/04/10
C-H activation
One-pot intramolecular cyclization
?-Pyrone derivatives
LDL uptaking
LXR-IDOL-LDLR axis
In vivo lipids-lowering effect
DCZ19931, a novel multi-targeting kinase inhibitor, inhibits ocular neovascularization
期刊论文
OAI收割
SCIENTIFIC REPORTS, 2022, 卷号: 12, 期号: 1, 页码: 15
作者:
Zhang, Huiying
;
Li, Bo
;
Ding, Jingjuan
;
Ye, Rong
;
Xu, Zhijian
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/10/17
Disruption of C/EBP beta-Clec7a axis exacerbates neuroinflammatory injury via NLRP3 inflammasome-mediated pyroptosis in experimental neuropathic pain
期刊论文
OAI收割
JOURNAL OF TRANSLATIONAL MEDICINE, 2022, 卷号: 20, 期号: 1, 页码: 19
作者:
Wu, Dan
;
Zhang, Yanqiong
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/04/10
C/EBP beta-Clec7a axis
Neuroinflammation
Neuropathic Pain
NLRP3 Inflammasome-mediated Pyroptosis
Suppression of Pathological Ocular Neovascularization by a Small Molecular Multi-Targeting Kinase Inhibitor, DCZ19903
期刊论文
OAI收割
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2022, 卷号: 11, 期号: 12, 页码: 15
作者:
Ding, Jingjuan
;
Li, Bo
;
Zhang, Huiying
;
Xu, Zhijian
;
Zhang, Qiuyang
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/10/17
ocular neovascularization
DCZ19903
multitarget kinase inhibitor
network pharmacology
MAPK signaling pathway
D3AI-Spike: A deep learning platform for predicting binding affinity between SARS-CoV-2 spike receptor binding domain with multiple amino acid mutations and human angiotensin-converting enzyme 2
期刊论文
OAI收割
COMPUTERS IN BIOLOGY AND MEDICINE, 2022, 卷号: 151, 页码: 8
作者:
Han, Jiaxin
;
Liu, Tingting
;
Zhang, Xinben
;
Yang, Yanqing
;
Shi, Yulong
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/04/10
D3AI-Spike
ELISA
Protein -protein interaction
COVID-19
Deep learning
Interfacial structures and decomposition reactions of hybrid anion-based ionic liquids at lithium metal surface from first-principles and ab initio molecular dynamics
期刊论文
OAI收割
JOURNAL OF MOLECULAR LIQUIDS, 2022, 卷号: 366, 页码: 11
作者:
Lu, Yunxiang
;
Tian, Ye
;
Xu, Zhijian
;
Liu, Honglai
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/11/11
Ionic liquids
Hybrid anions
SEI
Interfacial
Decomposition
Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay
期刊论文
OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2022, 页码: 11
作者:
Zhou, Liping
;
Liu, Tingting
;
Mo, Mengxia
;
Shi, Yulong
;
Wu, Leyun
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/11/11
Rational Design and Identification of Novel Piperine Derivatives as Multichitinase Inhibitors
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2022, 卷号: 70, 期号: 33, 页码: 10326-10336
作者:
Jiang, Zhiyang
;
Shi, Dongmei
;
Li, Huilin
;
He, Danchan
;
Zhu, Kai
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/09/30
Asian corn borer
chitinase
piperine derivate
multichitinase inhibitor
insect growth regulator (IGR)
Chemo- and Site-Selective Lysine Modification of Peptides and Proteins under Native Conditions Using the Water-Soluble Zolinium
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 14
作者:
Sun, Haiguo
;
Xi, Mengyu
;
Jin, Qiang
;
Zhu, Zhengdan
;
Zhang, Yani
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/09/30
Parthenolide reveals an allosteric mode to inhibit the deISGylation activity of SARS-CoV-2 papain-like protease
期刊论文
OAI收割
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2022, 卷号: 54, 期号: 8, 页码: 1133-1139
作者:
Zou, Zhihui
;
Shan, Huizhuang
;
Sun, Demeng
;
Xia, Li
;
Shi, Yulong
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2022/11/11
COVID-19
SARS-CoV-2
PLpro
Parthenolide
deISGylation