机构

• 上海药物研究所 [190]

采集方式

• OAI收割 [190]

内容类型

• 期刊论文 [184]
• 会议论文 [6]

发表日期

• 2024 [4]
• 2023 [12]
• 2022 [10]
• 2021 [14]
• 2020 [5]
• 2019 [11]
• 更多

学科主题

• Pharmacolo... [5]
• Chemistry [3]
• Oncology [2]
• Biochemist... [1]
• Plant Scie... [1]

筛选

浏览/检索结果: 共190条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity 期刊论文  OAI收割 NATURE IMMUNOLOGY, 2024, 页码: 32 作者:  Long, Xuehui;  Zhang, Sulin;  Wang, Yuliang;  Chen, Jingjing;  Lu, Yanlai   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/03/25 A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy 期刊论文  OAI收割 CANCER COMMUNICATIONS, 2024, 页码: 5 作者:  Liu, Yingqiang;  Tong, Linjiang;  Zhang, Mengge   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/13 Nanobodies as negative allosteric modulators for human calcium sensing receptor 期刊论文  OAI收割 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 卷号: 695, 页码: 9 作者:  Cui, Qianqian;  Wang, Lu   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/04/09 G-protein-coupled receptor  Extracellular calcium sensing receptor  Nanobody  Cryo-electron microscope  Systemic Ca 2+homoeostasis   Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation 期刊论文  OAI收割 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13 作者:  Feng, Dazhi;  Liu, Bo;  Chen, Zhiwei;  Xu, Jinyi;  Geng, Meiyu   |  收藏  |  浏览/下载：24/0  |  提交时间：2024/02/27 HPK1 inhibitor  machine learning  virtual screening  free energy perturbation  structural modification   Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764 作者:  Liu, Yingqiang;  Zhan, Zhengsheng;  Kang, Zhuang;  Li, Mengyuan;  Lv, Yongcong   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/01/26 Small molecule inhibitor  Tumor microenvironment  Immune-checkpoint  immune-deficient mouse models  including temozolomide (TMZ) insensitive tumors. Notably   Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide   High-throughput design of energetic molecules 期刊论文  OAI收割 JOURNAL OF MATERIALS CHEMISTRY A, 2023, 卷号: 11, 期号: 45, 页码: 25031-25044 作者:  Liu, Jian;  Zhao, Shicao;  Duan, Bowen;  He, Xudong;  Yang, Chunming   |  收藏  |  浏览/下载：4/0  |  提交时间：2023/12/19 Development of a novel 18F-labeled small molecule probe for PET imaging of mesenchymal epithelial transition receptor expression 期刊论文  OAI收割 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2023, 页码: 13 作者:  Bu, Lihong;  Ma, Xiaowei;  Ji, Aiyan;  Geng, Kaijun;  Feng, Hongyan   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/12/19 Mesenchymal epithelial transition receptor  Gliomas  [18F]-AZC  PET  Quinoline derivative compound   Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes 期刊论文  OAI收割 JOURNAL OF STRUCTURAL BIOLOGY, 2023, 卷号: 215, 期号: 3, 页码: 9 作者:  Sun, Zengchao;  Wang, Lu;  Li, Lingyun;  Sun, Yili;  Zhang, Daizhou   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/10/17 SARS-CoV-2 virus  Receptor -binding domain  Nanobody  Crystal structure  Conservative binding epitope  Bi-paratopic nanobodies   Impact of SARS-CoV-2 envelope protein mutations on the pathogenicity of Omicron XBB 期刊论文  OAI收割 CELL DISCOVERY, 2023, 卷号: 9, 期号: 1, 页码: 4 作者:  Wang, Yi;  Pan, Xiaoyan;  Ji, Hongying;  Zuo, Xiaoli;  Xiao, Geng-Fu   |  收藏  |  浏览/下载：18/0  |  提交时间：2023/10/17