中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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浏览/检索结果: 共13条,第1-10条 帮助

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Identification and structural insight of an effective PPAR gamma modulator with improved therapeutic index for anti-diabetic drug discovery 期刊论文  OAI收割
CHEMICAL SCIENCE, 2020, 卷号: 11, 期号: 8, 页码: 2260-2268
作者:  
Jiang, Haowen;  Zhou, X. Edward;  Shi, Jingjing;  Zhou, Zhi;  Zhao, Guanguan
  |  收藏  |  浏览/下载:22/0  |  提交时间:2020/07/01
Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK) 期刊论文  OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 44, 页码: 16994-17007
作者:  
Gu, Xin;  Bridges, Michael D.;  Yan, Yan;  de Waal, Parker W.;  Zhou, X. Edward
  |  收藏  |  浏览/下载:68/0  |  提交时间:2019/01/08
Crystal structure of the Frizzled 4 receptor in a ligand-free state 期刊论文  OAI收割
NATURE, 2018, 卷号: 560, 期号: 7720, 页码: 666-+
作者:  
Yang, Shifan;  Wu, Yiran;  Xu, Ting-Hai;  de Waal, Parker W.;  He, Yuanzheng
  |  收藏  |  浏览/下载:81/0  |  提交时间:2019/01/08
Identification of a novel selective PPAR gamma ligand with a unique binding mode and improved therapeutic profile in vitro 期刊论文  OAI收割
Scientific Reports, 2017, 卷号: 7
作者:  
Yi, Wei;  Shi, Jingjing;  Zhao, Guanguan;  Zhou, X. Edward;  Suino-Powell, Kelly
  |  收藏  |  浏览/下载:16/0  |  提交时间:2019/01/08
X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex 期刊论文  OAI收割
SCIENTIFIC DATA, 2016, 卷号: 3
作者:  
Zhou, X. Edward;  Gao, Xiang;  Barty, Anton;  Kang, Yanyong;  He, Yuanzheng
  |  收藏  |  浏览/下载:25/0  |  提交时间:2019/01/08
FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of beta-Klotho 期刊论文  OAI收割
MOLECULAR ENDOCRINOLOGY, 2016, 卷号: 30, 期号: 1, 页码: 92-103
作者:  
Fu, Ting;  Kim, Young-Chae;  Byun, Sangwon;  Kim, Dong-Hyun;  Seok, Sunmi
  |  收藏  |  浏览/下载:23/0  |  提交时间:2019/01/08
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser 期刊论文  OAI收割
NATURE, 2015, 卷号: 523, 期号: 7562, 页码: 561-+
作者:  
Kang, Yanyong;  Zhou, X. Edward;  Gao, Xiang;  He, Yuanzheng;  Liu, Wei
  |  收藏  |  浏览/下载:36/0  |  提交时间:2019/01/08
Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis 期刊论文  OAI收割
CELL METABOLISM, 2014, 卷号: 20, 期号: 2, 页码: 320-332
作者:  
Li, Shuangwei;  Hsu, Diane D. F.;  Li, Bing;  Luo, Xiaolin;  Alderson, Nazilla
  |  收藏  |  浏览/下载:19/0  |  提交时间:2019/01/08
Structures and mechanism for the design of highly potent glucocorticoids 期刊论文  OAI收割
CELL RESEARCH, 2014, 卷号: 24, 期号: 6, 页码: 713-726
作者:  
He, Yuanzheng;  Yi, Wei;  Suino-Powell, Kelly;  Zhou, X. Edward;  Tolbert, W. David
  |  收藏  |  浏览/下载:16/0  |  提交时间:2019/01/08
Structural insights into gene repression by the orphan nuclear receptor SHP 期刊论文  OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 卷号: 111, 期号: 2, 页码: 839-844
作者:  
Zhi, Xiaoyong;  Zhou, X. Edward;  He, Yuanzheng;  Zechner, Christoph;  Suino-Powell, Kelly M.
  |  收藏  |  浏览/下载:13/0  |  提交时间:2019/01/08