An Improved Iodine-Catalyzed Aromatization Reaction and Its Application in the Synthesis of a Key Intermediate of Cannabidiol
文献类型：期刊论文
| 作者 | Abduahadi, Safomuddin3,4; Bonku, Emmanuel Mintah3,4; Qin, Hongjian2,3; Odilov, Abdullajon3,4; Zhu, Fuqiang1; Aisa, Haji Akber2,3; Shen, Jingshan3,4
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| 刊名 | SYNLETT
 |
| 出版日期 | 2024-04-22 |
| 页码 | 6 |
| 关键词 | methyl olivetolate potassium persulfate aromatization oxidation iodine-catalyst cannabidiol |
| ISSN号 | 0936-5214 |
| DOI | 10.1055/a-2301-2431 |
| 通讯作者 | Zhu, Fuqiang(fuqiang.zhu@topharman.com) ; Shen, Jingshan(shenjingshan@simm.ac.cn) |
| 英文摘要 | In this study, the development of an improved process for the synthesis of a key cannabidiol intermediate, methyl olivetolate, is described. The process involves an improvement of the iodine-catalyzed aromatization of cyclohexanone using potassium persulfate as an oxidant. This approach enabled for the efficient synthesis of methyl olivetolate with a 90% yield and 99.84% HPLC purity on a 5 kg scale. Additionally, a total of 19 cyclohexanone substrates afforded higher yields (71-92%) of m-diphenol compounds compared to the established methods. |
| 资助项目 | Alliance of International Science Organizations |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001206853500002 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310647]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhu, Fuqiang; Shen, Jingshan |
| 作者单位 | 1.Topharman Shanghai Co Ltd, 388 Jialilue Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plants, Urumqi 830011, Xinjiang, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Abduahadi, Safomuddin,Bonku, Emmanuel Mintah,Qin, Hongjian,et al. An Improved Iodine-Catalyzed Aromatization Reaction and Its Application in the Synthesis of a Key Intermediate of Cannabidiol[J]. SYNLETT,2024:6. |
| APA | Abduahadi, Safomuddin.,Bonku, Emmanuel Mintah.,Qin, Hongjian.,Odilov, Abdullajon.,Zhu, Fuqiang.,...&Shen, Jingshan.(2024).An Improved Iodine-Catalyzed Aromatization Reaction and Its Application in the Synthesis of a Key Intermediate of Cannabidiol.SYNLETT,6. |
| MLA | Abduahadi, Safomuddin,et al."An Improved Iodine-Catalyzed Aromatization Reaction and Its Application in the Synthesis of a Key Intermediate of Cannabidiol".SYNLETT (2024):6. |
入库方式： OAI收割
来源：上海药物研究所
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