Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates
文献类型：期刊论文
| 作者 | Xiang, Li1,5,6; Qin, Jishan1,5; Kushatov, Temur4; Tursunov, Firdavsi4; Farmonov, Ozod1,5; Jiang, Xiangrui1,2,5; Yang, Feipu5; Shen, Jingshan1,5; Bozorov, Khurshed4; Aisa, Haji Akber1,3,6 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2025-11-26 |
| 页码 | 13 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.5c01211 |
| 英文摘要 | The first asymmetric total synthesis of the bisbenzylisoquinoline alkaloids berbamine (1a) and oxyacanthine (1b) has been accomplished by employing Noyori asymmetric hydrogenation for chirality installation and leveraging copper-mediated Ullmann coupling for macrocycle formation. Our synthesis unequivocally confirmed the sample misidentification of 1a, as indicated in our previous work. Evaluation of anti-inflammatory activities revealed that both synthetic and natural berbamine or oxyacanthine comparably suppressed gene expression of pro-inflammatory cytokines IL-6 and IL-1 beta in LPS-stimulated RAW 264.7 macrophages. Notably, intermediate 15a displayed potent anti-inflammatory activity coupled with minimal cytotoxicity, emerging as a promising lead candidate for the development of novel anti-inflammatory agents. |
| WOS关键词 | BISBENZYLISOQUINOLINE ALKALOIDS ; ENANTIOSELECTIVE SYNTHESIS ; BERBAMUNINE |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001624965300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322091]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Bozorov, Khurshed; Aisa, Haji Akber |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 10049, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Xinjiang Med Univ, Sch Pharm, Urumqi 830054, Peoples R China 4.Samarkand State Univ, Inst Biochem, Dept Organ Synth & Bioorgan Chem, Samarkand 140104, Uzbekistan 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plants, Urumqi 830011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiang, Li,Qin, Jishan,Kushatov, Temur,et al. Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates[J]. JOURNAL OF NATURAL PRODUCTS,2025:13. |
| APA | Xiang, Li.,Qin, Jishan.,Kushatov, Temur.,Tursunov, Firdavsi.,Farmonov, Ozod.,...&Aisa, Haji Akber.(2025).Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates.JOURNAL OF NATURAL PRODUCTS,13. |
| MLA | Xiang, Li,et al."Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates".JOURNAL OF NATURAL PRODUCTS (2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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