中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [25]
动物研究所 [1]
上海营养与健康研究所 [1]
昆明动物研究所 [1]
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OAI收割 [28]
内容类型
期刊论文 [28]
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2023 [1]
2022 [3]
2019 [1]
2018 [1]
2016 [3]
2015 [3]
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内容类型:期刊论文
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Ligand activation mechanisms of human KCNQ2 channel
期刊论文
OAI收割
Nature communications, 2023, 卷号: 14, 期号: 1, 页码: 6632
作者:
Ma, Demin
;
Zheng, Yueming
;
Li, Xiaoxiao
;
Zhou, Xiaoyu
;
Yang, Zhenni
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/03/26
Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation
期刊论文
OAI收割
NEUROBIOLOGY OF DISEASE, 2022, 卷号: 174, 页码: 10
作者:
Tian, Fuyun
;
Cao, Birong
;
Xu, Haiyan
;
Zhan, Li
;
Nan, Fajun
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/12/13
KCNQ2
Epilepsy
Mouse model
HN37 (pynegabine)
Diversity-oriented synthesis of marine polybrominated diphenyl ethers as potential KCNQ potassium channel activators
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2022, 卷号: 126, 页码: 105909
作者:
Liu, Lai-Xin
;
Gu, Ru-Rong
;
Jin, Yang
;
Chen, Xue-Qin
;
Li, Xu-Wen
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/03/21
Marine Natural product
Polybrominated diphenyl ethers
KCNQ potassium channel
General Pharmacological Activation Mechanism of K+ Channels Bypassing Channel Gates
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15
作者:
Liu, Shijie
;
Guo, Peipei
;
Wang, Kun
;
Zhang, Shaoying
;
Li, Ya
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/08/30
Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 10, 期号: 1, 页码: 27-33
作者:
Wang, Lei
;
Qiao, Guan-Hua
;
Hu, Hai-Ning
;
Gao, Zhao-Bing
;
Nan, Fa-Jun
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
KCNQ channel
retigabine
subtype selectivity
agonist
A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Bai, Fang
;
Pi, Xiaoping
;
Li, Ping
;
Zhou, Pingzheng
;
Yang, Huaiyu
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
KCNQ2 potassium channel
hill equation
thermodynamic model
patch clamp electrophysiology
activators
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 1, 页码: 105-110
作者:
Yue, Jin-feng
;
Qiao, Guan-hua
;
Liu, Ni
;
Chen, Xue-qin
;
Nan, Fa-jun
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
KCNQ potassium channels in sensory system and neural circuits
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 1, 页码: 25-33
作者:
Wang, Jing-jing
;
Li, Yang
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
KCNQ channels
M channels
neural circuits
channelopathy
epilepsy
neuropathic pain
deafness
mental illness
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clampbased high-throughput screening techniques
期刊论文
OAI收割
Acta Pharmacologica Sinica, 2016, 卷号: 37, 期号: 1, 页码: 105
作者:
Yue Jinfeng
;
Qiao Guanhua
;
Liu Ni
;
Chen Xueqin
;
Nan Fajun
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
POTASSIUM CHANNEL
KV7 CHANNELS
EPILEPSY
IDENTIFICATION
GENE
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation
期刊论文
OAI收割
SCIENTIFIC REPORTS, 2015, 卷号: 5
作者:
Chen, Liping
;
Zhang, Qiansen
;
Qiu, Yunguang
;
Li, Zanyuan
;
Chen, Zhuxi
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08