机构

• 上海药物研究所 [9]

采集方式

• OAI收割 [9]

内容类型

• 期刊论文 [9]

发表日期

• 2023 [9]

学科主题

筛选

浏览/检索结果: 共9条，第1-9条 帮助 限定条件 发表日期：2023    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序题名升序题名降序作者升序作者降序发表日期升序发表日期降序 Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764 作者:  Liu, Yingqiang;  Zhan, Zhengsheng;  Kang, Zhuang;  Li, Mengyuan;  Lv, Yongcong   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/01/26 Small molecule inhibitor  Tumor microenvironment  Immune-checkpoint  immune-deficient mouse models  including temozolomide (TMZ) insensitive tumors. Notably   Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259, 页码: 19 作者:  Wang, Pingyuan;  Zhu, Wen-Ting;  Wang, Yajing;  Song, Shan-Shan;  Xi, Yong   |  收藏  |  浏览/下载：59/0  |  提交时间：2023/10/17 PARP1 inhibitor  Synthetic lethality  Drug resistance  Anticancer  Structure -activity relationship   Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology 期刊论文  OAI收割 SCIENCE TRANSLATIONAL MEDICINE, 2023, 卷号: 15, 期号: 706, 页码: 15 作者:  Ji, Shuyi;  Feng, Li;  Fu, Zile;  Wu, Gaohua;  Wu, Yingcheng   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/10/17 Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis The EXIT-SEP Randomized Clinical Trial 期刊论文  OAI收割 JAMA INTERNAL MEDICINE, 2023, 卷号: 183, 期号: 7, 页码: 647-655 作者:  Liu, Songqiao;  Yao, Chen;  Xie, Jianfeng;  Liu, Hong;  Wang, Hongliang   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/03/27 Scalarane sesterterpenes from the South China Sea sponge Hyrtios erecta and their PTP1B inhibitory activity 期刊论文  OAI收割 TETRAHEDRON, 2023, 卷号: 137, 页码: 5 作者:  Sun, Li-Li;  Shen, Yi-Ran;  Li, Jia;  Wang, Jian-Rong;  Li, Xu-Wen   |  收藏  |  浏览/下载：23/0  |  提交时间：2023/10/17 Sponge  Hyrtios erecta  Scalarane-type sesterterpene  Configuration  PTP1B   Rh-Catalyzed C-H Activation/Annulation of Enaminones and Cyclic 1,3-Dicarbonyl Compounds: An Access to Isocoumarins 期刊论文  OAI收割 JOURNAL OF ORGANIC CHEMISTRY, 2023, 卷号: 88, 期号: 9, 页码: 5348-5358 作者:  Wang, Qian;  Li, Ying;  Sun, Jina;  Chen, Shiyu;  Li, Hui   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/03/27 Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design 期刊论文  OAI收割 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2023, 卷号: 89, 期号: 3 作者:  Gao, Qilin;  Ma, Bingbing;  Wang, Qianwen;  Zhang, Hao;  Fushinobu, Shinya   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/03/27 P450  testosterone  androstenedione  crystal structure  rational design   Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance 期刊论文  OAI收割 EMBO MOLECULAR MEDICINE, 2023, 页码: 24 作者:  Wang, Li-Min;  Wang, Pingyuan;  Chen, Xiao-Min;  Yang, Hui;  Song, Shan-Shan   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/04/10 homologous recombination repair  olaparib-resistant  PARP inhibitor  PARP7  type I interferons   Design, synthesis and biological evaluation of KRASG12C-PROTACs 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14 作者:  Zhang, Xiaoyi;  Zhao, Tong;  Sun, Minghao;  Li, Pei;  Lai, Mengzhen   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/04/10 KRASG12C  PROTAC  Covalent inhibitors  Structure-activity relationships (SARs)  Anticancer