机构

• 上海药物研究所 [24]

采集方式

• OAI收割 [24]

内容类型

• 期刊论文 [24]

发表日期

• 2023 [24]

学科主题

筛选

浏览/检索结果: 共24条，第1-10条 帮助 限定条件 发表日期：2023    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序题名升序题名降序作者升序作者降序发表日期升序发表日期降序 Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/02/19 A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects 期刊论文  OAI收割 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9 作者:  Yang, Xin-Mei;  Yang, Yang;  Yao, Bu-Fan;  Ye, Pan-Pan;  Xu, Yan   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/12/11 COVID-19  Simnotrelvir  Safety  Pharmacokinetics  Healthy subjects   Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids 期刊论文  OAI收割 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2023, 卷号: 185, 页码: 13-25 作者:  Zhao, Chengcheng;  Jiang, Xiangrui;  Peng, Liyuan;  Zhang, Yan;  Li, Huihui   |  收藏  |  浏览/下载：30/0  |  提交时间：2024/01/16 Heart failure  Hypertrophy  Epoxyeicosatrienoic acids  Soluble epoxide hydrolase   An efficient, concise synthetic approach to γ-aminobutyric acid (GABA) derivatives bearing bicyclo[2.2.2]octane and bicyclo[2.2.1]heptane rings 期刊论文  OAI收割 SYNTHETIC COMMUNICATIONS, 2023, 页码: 10 作者:  Luo, Wen;  Cheng, Xinqiang;  Zhu, Xinyuan;  Li, Yong;  Liu, Yongjia   |  收藏  |  浏览/下载：34/0  |  提交时间：2024/01/16 Diels-Alder cycloaddition  bridged bicyclic ring  S(N)2 alkylation  gamma-aminobutyric acid (GABA)  stereochemistry   SGF29 nuclear condensates reinforce cellular aging 期刊论文  OAI收割 CELL DISCOVERY, 2023, 卷号: 9, 期号: 1, 页码: 21 作者:  Yan, Kaowen;  Ji, Qianzhao;  Zhao, Dongxin;  Li, Mingheng;  Sun, Xiaoyan   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/12/11 Ligand activation mechanisms of human KCNQ2 channel 期刊论文  OAI收割 Nature communications, 2023, 卷号: 14, 期号: 1, 页码: 6632 作者:  Ma, Demin;  Zheng, Yueming;  Li, Xiaoxiao;  Zhou, Xiaoyu;  Yang, Zhenni   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/03/26 Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15 作者:  Jiang, Xiangrui;  Su, Haixia;  Shang, Weijuan;  Zhou, Feng;  Zhang, Yan   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/03/25 Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARa nucleus-cytoplasm shuttling 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 18 作者:  Zhong, Jing;  He, Xiaofang;  Gao, Xinxin;  Liu, Qiaohong;  Zhao, Yu   |  收藏  |  浏览/下载：5/0  |  提交时间：2023/12/08 Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 14 作者:  Li, Cuixia;  Wu, Yiran;  Wang, Wenli;  Xu, Lu;  Zhou, Yan   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/10/17 Spectral and biodistributional engineering of deep near-infrared chromophore 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 9, 页码: 7 作者:  Dong, Yan;  Lu, Xicun;  Li, Yi;  Chen, Weichao;  Yin, Lei   |  收藏  |  浏览/下载：22/0  |  提交时间：2023/10/17 Near infrared fluorophore  In vivo imaging  Molecular engineering  Biological distribution  Angiography