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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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昆明植物研究所 [20]
上海药物研究所 [8]
中国科学院大学 [8]
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Discovery of a PROTAC degrader for METTL3-METTL14 complex
期刊论文
OAI收割
CELL CHEMICAL BIOLOGY, 2024, 卷号: 31, 期号: 1, 页码: 25
作者:
Du, Wenhao
;
Huang, Yuting
;
Chen, Xiaoai
;
Deng, Yue
;
Sun, Yaoliang
  |  
收藏
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浏览/下载:1/0
  |  
提交时间:2024/05/07
Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 17
作者:
Zhang, Ranran
;
Wang, Pengyu
;
Wei, Bingyan
;
Chen, Liang
;
Song, Xiaomin
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/10/17
ClpP agonists
Structure-activity relationship
Mitochondrial respiratory chain
Antileukemic therapy
Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 22
作者:
Xiao, Pan
;
Duan, Zongliang
;
Liu, Zeyu
;
Chen, Liang
;
Zhang, Deyan
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/10/17
Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 9, 页码: 8113
作者:
Xu,Xinglian
;
Deng,Lulu
;
Tang,Yaling
;
Li,Jiang
;
Zhong,Ting
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/09
leukemia
sanguinarine
c-MET
MAPK
PI3K/mTOR
STAT3
MET
Oridonin inhibits DNMT3A R882 mutation-driven clonal hematopoiesis and leukemia by inducing apoptosis and necroptosis
期刊论文
OAI收割
CELL DEATH DISCOVERY, 2021, 卷号: 7, 期号: 1, 页码: 12
作者:
Liao, Min
;
Dong, Qiongye
;
Chen, Ruiqing
;
Xu, Liqian
;
Jiang, Yuxuan
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2021/12/01
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
Paris Saponin VII Induces Apoptosis and Cell Cycle Arrest in Erythroleukemia Cells by a Mitochondrial Membrane Signaling Pathway
期刊论文
OAI收割
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2021, 卷号: 21, 期号: 4, 页码: 498-507
作者:
Lin,Xin
;
Gajendran,Babu
;
Varier,Krishnapriya M.
;
Liu,Wuling
;
Song,Jingrui
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收藏
  |  
浏览/下载:35/0
  |  
提交时间:2022/04/02
Leukemia
Paris Saponin VII
HEL
cell cycle
apoptosis
membrane signaling pathway
Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 4, 页码: 589-603
作者:
Liu, Xiaoqi
;
Hu, Yuanyuan
;
Gao, Anhui
;
Xu, Meng
;
Gao, Lixin
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
3-Aryl-4-indolyl-maleimides
IDH1/R132H inhibitors
Tumor 2-HG
Synthesis
Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis
期刊论文
OAI收割
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 11
作者:
Liu, Tangjingjun
;
Xia, Lei
;
Yao, Yao
;
Yan, Chen
;
Fan, Yanhua
  |  
收藏
  |  
浏览/下载:74/0
  |  
提交时间:2019/04/15
Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 765-780
作者:
Lin, Xin
;
Tian, Dongsong
;
Fu, Yanhui
;
Li, Yanan
;
Huang, Liejun
  |  
收藏
  |  
浏览/下载:145/0
  |  
提交时间:2019/03/18
Polycyclic polyprenylated acylphloroglucinol
Chemical transformation
Cytotoxicity
Cell apoptosis
Cell cycle arrest