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The Tyrosine Kinase Inhibitor Bafetinib Inhibits PAR2-induced Activation of TRPV4 In Vitro and Pain In Vivo1
期刊论文
OAI收割
出版物, 2111, 页码: 1-44
Authors:
1M S Grace
;
T Lieu
;
B Darby
;
F C Abogadie
;
N Veldhuis N W Bunnett
;
P McIntyre
  |  
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  |  
View/Download:241/0
  |  
Submit date:2017/07/24
Transient Receptor Potential Ion Channel
Trpv4
Protease Activated Receptor
Par2
Pain
Tyrosine Kinase
Bafetinib
Simultaneous determination of unecritinib (TQ-B3101) and its active metabolite crizotinib in rat plasma by LC-MS/MS:An application to pharmacokinetic studies
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 246, 页码: 9
Authors:
Wang, Hong
;
Chen, Huixian
;
Cui, Xinran
;
Zhang, Yuchen
;
Zhou, Jialan
  |  
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  |  
View/Download:11/0
  |  
Submit date:2024/07/12
Unecritinib (TQ-B3101)
Crizotinib
Carboxylesterases
LC-MS/MS
Hydrolytic metabolism
Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5
H
-pyrrolo[1,2-
b
][1,2,4]triazole derivatives as necroptosis inhibitors
期刊论文
OAI收割
RSC MEDICINAL CHEMISTRY, 2024, 卷号: 15, 期号: 7, 页码: 2514-2526
Authors:
Jin, Zechen
;
Dai, Yang
;
Ji, Yinchun
;
Peng, Xia
;
Duan, Wenhu
  |  
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  |  
View/Download:4/0
  |  
Submit date:2024/08/20
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13
Authors:
Yang, Ying
;
Suo, Na
;
Cui, Shi-hao
;
Wu, Xuan
;
Ren, Xin-yue
  |  
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View/Download:6/0
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Submit date:2024/07/12
oligodendrocyte differentiation
oligodendrocyte progenitor cell
remyelination
trametinib
MEK inhibitor
MEK/ERK pathway
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
Authors:
Song, Pei-ran
;
Wan, Zhi-peng
;
Huang, Ge-ge
;
Song, Zi-lan
;
Zhang, Tao
  |  
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  |  
View/Download:22/0
  |  
Submit date:2024/07/12
diffuse large B-cell lymphoma
BTK inhibitors
drug resistance
BTK C481F
BTK A428D
SYHA1813
Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 期号: 1, 页码: 15
Authors:
He, Fenglian
;
Wu, Zhongen
;
Liu, Chenglong
;
Zhu, Yuanyuan
;
Zhou, Yan
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View/Download:14/0
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Submit date:2024/07/12
Identification of 1,3,4-Thiadiazolyl-Containing Thiazolidine-2,4-dione Derivatives as Novel PTP1B Inhibitors with Antidiabetic Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 10, 页码: 8406-8419
Authors:
Li, Mengyue
;
Li, Huiyun
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View/Download:19/0
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Submit date:2024/06/27
A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease
期刊论文
OAI收割
MOLECULES, 2024, 卷号: 29, 期号: 8, 页码: 17
Authors:
Huang, Yuqing
;
Ning, Yi
;
Chen, Zhiwei
;
Song, Peiran
;
Tang, Haotian
  |  
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View/Download:7/0
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Submit date:2024/05/31
IRAK4 inhibitor
peritonitis
inflammatory bowel disease (IBD)
macrophage
RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells
期刊论文
OAI收割
CELL DEATH DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 12
Authors:
Yang, Tao
;
Xiang, Cai-gui
;
Wang, Xiao-han
;
Li, Qing-qing
;
Lei, Shu-yue
  |  
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  |  
View/Download:11/0
  |  
Submit date:2024/05/07
Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase
期刊论文
OAI收割
ACS CHEMICAL BIOLOGY, 2024, 页码: 12
Authors:
Zhang, Huimin
;
Xu, Dounan
;
Huang, Hongchan
;
Jiang, Hao
;
Hu, Linghao
  |  
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View/Download:13/0
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Submit date:2024/05/07