中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
地理科学与资源研究... [11]
上海药物研究所 [10]
生态环境研究中心 [9]
武汉岩土力学研究所 [5]
高能物理研究所 [4]
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期刊论文 [47]
中文期刊论文 [6]
会议论文 [4]
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2024 [5]
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Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 15
作者:
Liu, Yadan
;
Ye, Jialin
;
Fan, Zisheng
;
Wu, Xiaolong
;
Zhang, Yinghui
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/12/16
cGAS-STING signaling
Ginkgetin
senescence
STING inhibitor
target identification
An updated patent review of SOS1 inhibitors (2022-present)
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2024, 页码: 15
作者:
Zhou, Guizhen
;
Zhou, Chuan
;
Ma, Xinyi
;
Xu, Jiahang
;
Zhou, Zehui
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/12/11
SOS1
KRAS
cancer
inhibitor
drug discovery
Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido [2,3-
d
]pyrimidin-7-one-based SOS1 inhibitor
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 107, 页码: 9
作者:
Wang, Kun
;
Zhou, Zehui
;
Ma, Xinyi
;
Xu, Jiahang
;
Xu, Wangyang
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/07/12
SOS1
KRAS mutation
PROTAC
Anti-cancer activity
Roles of photochemical consumption of VOCs on regional background O3 concentration and atmospheric reactivity over the pearl river estuary, Southern China
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 卷号: 928, 页码: 10
作者:
Sun, Jiayin
;
Yu, Xiaoyu
;
Ling, Zhenhao
;
Fang, Guizhen
;
Ming, Lili
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/09/13
Volatile organic compounds
Regional background O3 concentration
Atmospheric reactivity
Pearl River Estuary
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS
G12D
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1147-1167
作者:
Zhou, Chuan
;
Fan, Zisheng
;
Gu, Yuejiao
;
Ge, Zhiming
;
Tao, Zhaofan
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2024/02/27
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 6, 页码: 4197-4214
作者:
Zhou, Zehui
;
Zhou, Guizhen
;
Zhou, Chuan
;
Fan, Zisheng
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/03/27
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3327-3347
作者:
Shan, Bin
;
Hou, Hui
;
Zhang, Keke
;
Li, Rui
;
Shen, Chang
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/03/27
Design, Synthesis, and Bioevaluation of Pyrido[2,3-d]pyrimidin-7-ones as Potent SOS1 Inhibitors
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2023, 页码: 183-190
作者:
Liu, Meiying
;
Zhou, Guizhen
;
Su, Wenhong
;
Gu, Yuejiao
;
Gao, Mingshan
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/03/27
KRAS mutation
SOS1-KRAS interaction
SOS1 inhibitor
combination therapy
Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 5, 页码: 2619-2622
作者:
Chang, Jie
;
Yang, Ruirui
;
Chen, Lifan
;
Fan, Zisheng
;
Zhou, Jingyi
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2022/08/16
ADP-ribosylation factor 1
Breast cancer
Demethylzeylasteral
Virtual screening
Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 5, 页码: 3923-3942
作者:
Zhou, Chuan
;
Fan, Zisheng
;
Zhou, Zehui
;
Li, Yupeng
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2022/06/15