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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [122]
青海盐湖研究所 [54]
大连化学物理研究所 [38]
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Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-D-aspartate (NMDA) receptor and monoamine transporter for treating depression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 20
作者:
Zheng, Fuqiang
;
Hu, Zhengtao
;
Chen, Hai
;
Cheng, Jiaxin
;
Hou, Qiongqiong
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收藏
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浏览/下载:0/0
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提交时间:2025/06/23
Heterocycle-fused phenylcyclohexylamines
Multi-target antagonists
NMDAR
Monoamine transporter
Antidepressants
Discovery of multi-chitinase inhibitors cinnamyl thiazolidinone compounds as candidates for insect growth regulators via ligand-based optimization strategies
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 卷号: 306, 页码: 14
作者:
Jiang, Zhiyang
;
Shi, Dongmei
;
Fu, Haoyu
;
Li, Yan
;
Zou, Renxuan
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浏览/下载:0/0
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提交时间:2025/05/27
Multi-chitinase inhibitor
Cinnamaldehyde compounds
Thiazolidinone compounds
Ligand-based optimization
Insect growth regulators (IGRs)
Targeting Two Odorant-Binding Proteins in Acyrthosiphon pisum: Discovery of Novel Jasmone Derivatives as Aphid Repellents
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2025, 卷号: 73, 期号: 19, 页码: 11998-12013
作者:
Zhu, Ziwei
;
Li, Huilin
;
Zhu, Wenya
;
Du, Shaoqing
;
Yang, Zhaokai
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浏览/下载:0/0
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提交时间:2025/06/23
odorant-binding proteins
jasmone derivatives
rational design
aphid repellents
insect behaviorregulators
Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors
期刊论文
OAI收割
COMMUNICATIONS CHEMISTRY, 2025, 卷号: 8, 期号: 1, 页码: 13
作者:
Gulyas, Kinga Virag
;
Zhou, Liping
;
Salamonsen, Daniel
;
Prester, Andreas
;
Bartels, Kim
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浏览/下载:0/0
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提交时间:2025/06/23
Development of RelB-targeting small-molecule inhibitors of non-canonical NF-kB signaling with antitumor efficacy
期刊论文
OAI收割
MOLECULAR THERAPY, 2025, 卷号: 33, 期号: 4, 页码: 1519-1534
作者:
Li, Cuifeng
;
Wei, Shuqi
;
Sun, Donglin
;
Yang, Zhuo
;
Wang, Qi
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浏览/下载:0/0
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提交时间:2025/05/27
Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 337, 页码: 11
作者:
Tang, Bixi
;
Xie, Like
;
Wang, Yangyang
;
Shi, Yulong
;
Kan, Weijuan
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收藏
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浏览/下载:16/0
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提交时间:2024/11/26
Lung first-pass effect
Tanreqing injection
Pharmacokinetics
Sepsis-associated acute lung injury
Acute respiratory distress syndrome
B(MIDA)-directed site-selective intermolecular halofluoroalkylation of alkenes: synthesis of diversely functionalized building blocks
期刊论文
OAI收割
CHEMICAL SCIENCE, 2025, 页码: 8
作者:
Wu, Hengbo
;
Luo, Ruitong
;
Peng, Jingjing
;
Han, Zijian
;
Zhang, Renjie
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收藏
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浏览/下载:13/0
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提交时间:2025/04/01
F-CPI: A Multimodal Deep Learning Approach for Predicting Compound Bioactivity Changes Induced by Fluorine Substitution
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 13
作者:
Zhang, Qian
;
Yin, Wenhai
;
Chen, Xinyao
;
Zhou, Aimin
;
Zhang, Guixu
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收藏
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浏览/下载:13/0
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提交时间:2025/02/28
Identification of USP2 as a novel target to induce degradation of KRAS in myeloma cells
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 12, 页码: 5235-5248
作者:
Wang, Yingying
;
Zhang, Youping
;
Luo, Hao
;
Wei, Wei
;
Liu, Wanting
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收藏
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浏览/下载:18/0
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提交时间:2025/04/01
Ubiquitin-specific protease 2
KRAS
Gambogic acid
Multiple myeloma
Degradation
Ubiquitination
Allosteric pocket
Deubiquitination
Slow Metabolism-Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone-Induced Obesity-Specific Liver Injury
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 14
作者:
Li, Guanting
;
Hu, Yourong
;
Zhao, Han
;
Peng, Ziyu
;
Shang, Xin
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收藏
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浏览/下载:12/0
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提交时间:2025/01/06
benzbromarone
drug-induced liver injury
drug metabolism
obesity
PPAR gamma