机构

• 上海药物研究所 [36]
• 中国科学院大学 [4]
• 上海有机化学研究所 [3]
• 高能物理研究所 [3]
• 物理研究所 [2]
• 化学研究所 [2]
• 更多

采集方式

• OAI收割 [53]
• iSwitch采集 [4]

内容类型

• 期刊论文 [52]
• 专利 [2]
• 会议论文 [2]
• 学位论文 [1]

发表日期

• 2023 [2]
• 2022 [2]
• 2020 [2]
• 2017 [2]
• 2016 [6]
• 2015 [2]
• 更多

学科主题

• 物理化学 [2]
• 生命有机化学 [2]
• 天然产物有机化学 [1]

筛选

浏览/检索结果: 共57条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors 期刊论文  OAI收割 ARCHIV DER PHARMAZIE, 2024, 页码: 16 作者:  An, Yuxiang;  Peng, Xia;  Wang, Tianchen;  Liu, Kaiyuan;  Feng, Dazhi   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/12/25 inhibitor  pharmacokinetic study  pyridazin-4-one  receptor-interacting protein kinase 1  selectivity   Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764 作者:  Liu, Yingqiang;  Zhan, Zhengsheng;  Kang, Zhuang;  Li, Mengyuan;  Lv, Yongcong   |  收藏  |  浏览/下载：24/0  |  提交时间：2024/01/26 Small molecule inhibitor  Tumor microenvironment  Immune-checkpoint  immune-deficient mouse models  including temozolomide (TMZ) insensitive tumors. Notably   Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2023, 页码: 10 作者:  Zhou, Rongyao;  Wang, Xiyuan;  Zhang, Deqiang;  Zhan, Zhengsheng;  Duan, Wenhu   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/12/08 STING  CDN  Benzo[b]thiophene-2-carboxamide  Cellular activity   Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation 期刊论文  OAI收割 CELL DISCOVERY, 2022, 卷号: 8, 期号: 1, 页码: 17 作者:  Xie, Zuoquan;  Wang, Zhen;  Fan, Fengying;  Zhou, Jinpei;  Hu, Zhaoxue   |  收藏  |  浏览/下载：37/0  |  提交时间：2023/04/10 Smart drug delivery systems for precise cancer therapy 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 11, 页码: 4098-4121 作者:  Wang, Xiaoyou;  Li, Chong;  Wang, Yiguang;  Chen, Huabing;  Zhang, Xinxin   |  收藏  |  浏览/下载：34/0  |  提交时间：2023/04/10 Pharmaceutics  Smart drug delivery system  Stimuli-responsive  Receptor-ligand-based delivery  Nano-drug delivery systems  Precise therapy  Toxicity  Cancer   Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18 作者:  Xu, Dandan;  Sun, Deqiao;  Wang, Wei;  Peng, Xia;  Zhan, Zhengsheng   |  收藏  |  浏览/下载：52/0  |  提交时间：2021/08/17 Axl  Cancer  Inhibitor  Pyrrolo[2,3-d]pyrimidine   DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation 期刊论文  OAI收割 BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69 作者:  Lv, Jianlu;  Wang, Wei;  Zhu, Xialin;  Xu, Xiaoju;  Yan, Qiuying   |  收藏  |  浏览/下载：42/0  |  提交时间：2020/12/21 Alzheimer'sdisease  Microglia  AMPK alpha 1  DW14006  Phagocytosis  Neuro-inflammation   DW14006 as a Direct AMPK alpha Activator Ameliorates Diabetic Peripheral Neuropathy in Mice 期刊论文  OAI收割 DIABETES, 2020, 卷号: 69, 期号: 9, 页码: 1974-1988 作者:  Xu, Xu;  Wang, Wei;  Wang, Zhengyu;  Lv, Jianlu;  Xu, Xiaoju   |  收藏  |  浏览/下载：44/0  |  提交时间：2020/12/24 Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 20, 页码: 9085-9104 作者:  Wang, Yuming;  Li, Lijun;  Fan, Jun;  Dai, Yang;  Jiang, Alan   |  收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 页码: 128-152 作者:  Wang, Zhengyu;  Shi, Xiaofan;  Zhang, Huan;  Yu, Liang;  Cheng, Yanhua   |  收藏  |  浏览/下载：46/0  |  提交时间：2019/01/08 Type 2 diabetes mellitus  Hypoglycemia  Dyslipidemia  Glucokinase activators  N-Thiazol-2-yl-benzamides