机构

• 上海药物研究所 [11]
• 西北高原生物研究所 [9]
• 地理科学与资源研究所 [3]
• 重庆绿色智能技术研究... [2]
• 计算技术研究所 [1]
• 化学研究所 [1]
• 更多

采集方式

• OAI收割 [31]

内容类型

• 期刊论文 [27]
• 专利 [4]

发表日期

• 2024 [2]
• 2023 [3]
• 2022 [6]
• 2021 [1]
• 2020 [3]
• 2019 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共31条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands 期刊论文  OAI收割 NATURE METHODS, 2024, 页码: 17 作者:  Li, Kejia;  Chen, Shijie;  Wang, Keyun;  Wang, Yan;  Xue, Lianji   |  收藏  |  浏览/下载：12/0  |  提交时间：2025/01/14 Structure-Based Design and Discovery of a Potent and Cell-Active LC3A/B Covalent Inhibitor 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 14, 页码: 12184-12204 作者:  Zhou, Zhenfei;  Huang, Siqi;  Fan, Shijie;  Li, Xueyuan;  Wang, Chengyu   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/08/22 OTTM: an automated classification tool for translational drug discovery from omics data 期刊论文  OAI收割 BRIEFINGS IN BIOINFORMATICS, 2023, 页码: 12 作者:  Yang, Xiaobo;  Zhang, Bei;  Wang, Siqi;  Lu, Ye;  Chen, Kaixian   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/10/17 OTTM  omics data  translational drug discovery  literature mining  hepatocellular carcinoma   Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) inverse agonists 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 18 作者:  Lu, Lixue;  Chen, Song;  Yu, Mingcheng;  Zhou, Ronghui;  Guo, Siqi   |  收藏  |  浏览/下载：30/0  |  提交时间：2023/10/17 ROR gamma t  Triazines  Inverse agonist  Psoriasis  Autoimmune diseases   Design, synthesis of novel benzimidazole derivatives as ENL inhibitors suppressing leukemia cells viability via downregulating the expression of MYC 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 248, 页码: 14 作者:  Guo, Siqi;  Jia, Tongguan;  Xu, Xiaoming;  Yang, Feng;  Xiao, Senhao   |  收藏  |  浏览/下载：33/0  |  提交时间：2023/04/10 ENL Inhibitor  YEATS domain  Histone lysine acetylation  Benzimidazole derivatives  Acute myeloid leukemia   Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties 期刊论文  OAI收割 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1537-1555 作者:  Li, Ennian;  Wang, Kai;  Zhang, Bei;  Guo, Siqi;  Xiao, Senhao   |  收藏  |  浏览/下载：56/0  |  提交时间：2022/08/16 DNMT1 inhibitor  A549 cell lines  HCT116 cell lines  antitumor activity  pharmacokinetic   A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 4614 作者:  Wang, Yang;  Yuan, Wenjie;  Guo, Siqi;  Li, Qiqi;  Chen, Xiaomei   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/03/21 Distributed and Time-Delayed k-Winner-Take-All Network for Competitive Coordination of Multiple Robots 期刊论文  OAI收割 IEEE TRANSACTIONS ON CYBERNETICS, 2022, 页码: 12 作者:  Jin, Long;  Liang, Siqi;  Luo, Xin;  Zhou, Mengchu   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/08/22 Mathematical models  Delay effects  Task analysis  Robot kinematics  Multi-robot systems  Robustness  Heuristic algorithms  Competitive coordination  distributed control  intelligent network  k-winner-take-all (kWTA)  multirobot system  optimization  time delay   SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors 期刊论文  OAI收割 CELL RESEARCH, 2022, 页码: 21 作者:  Wang, Xiaomin;  Chen, Ziqi;  Xu, Jun;  Tang, Shuai;  An, Nan   |  收藏  |  浏览/下载：57/0  |  提交时间：2022/06/15 Soil pH changes in a small catchment on the Chinese Loess Plateau after long-term vegetation rehabilitation 期刊论文  OAI收割 ECOLOGICAL ENGINEERING, 2022, 卷号: 175, 页码: 10 作者:  Jin, Zhao;  Luo, Da;  Yu, Yunlong;  Yang, Siqi;  Zhang, Jing   |  收藏  |  浏览/下载：39/0  |  提交时间：2022/08/18 Afforestation  Catchment topography  Hydrogeochemical processes  Paired catchments