中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [14]
长春光学精密机械与物... [4]
金属研究所 [3]
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期刊论文 [34]
专利 [2]
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2025 [2]
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学科主题
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浏览/检索结果:
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Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel
Hs
ClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 4, 页码: 4287-4307
作者:
Sun, Mingyang
;
Chen, Beijing
;
Teng, Dan
;
Zhao, Hongshen
;
Liao, Yilie
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/04/01
Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282, 页码: 21
作者:
Sui, Qibang
;
Zhou, Yuanyang
;
Li, Manjia
;
Wang, Dan
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/12/25
Synthetic lethal
MSI tumors
WRN inhibitors
Triazolo-pyrimidine derivatives
Age-related decline in CD8
+
tissue resident memory T cells compromises antitumor immunity
期刊论文
OAI收割
NATURE AGING, 2024, 卷号: 4, 期号: 12, 页码: 1828-+
作者:
Pei, Siyu
;
Deng, Xiuyu
;
Yang, Ruirui
;
Wang, Hui
;
Shi, Jian-Hong
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/02/28
Discovery of CLPP-1071 as an Exceptionally Potent and Orally Efficacious Human ClpP Activator with Strong In Vivo Antitumor Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21
作者:
Chen, Beijing
;
Sun, Mingyang
;
Zhang, Chun
;
Huang, Qi
;
Teng, Dan
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/12/25
Sodium oligomannate disrupts the adherence of Rib
high
bacteria to gut epithelia to block SAA-triggered Th1 inflammation in 5XFAD transgenic mice
期刊论文
OAI收割
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 19
作者:
Wang, Xinyi
;
Xie, Zuoquan
;
Yuan, Jie
;
Jin, Enjing
;
Lian, Wen
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/12/16
Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis
期刊论文
OAI收割
ISCIENCE, 2024, 卷号: 27, 期号: 10, 页码: 23
作者:
Du, Runhua
;
Gao, Yanmei
;
Yan, Cong
;
Ren, Xuelian
;
Qi, Shankang
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/11/05
3D Noncontact Micro-Particle Manipulation With Acoustic Robot End-Effector Under Microscope
期刊论文
OAI收割
IEEE ROBOTICS AND AUTOMATION LETTERS, 2024, 卷号: 9, 期号: 9, 页码: 7979-7986
作者:
Wang, Mingyue
;
Li, Jiaqi
;
Jia, Yuyu
;
Sun, Zhenhuan
;
Su, Hu
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/09/09
Acoustics
End effectors
Three-dimensional displays
Robot kinematics
Impedance
Phased arrays
Acoustic field
micro/nano robotics
microscopic vision
noncontact particle manipulation
DNA-PK-Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance
期刊论文
OAI收割
CANCER RESEARCH, 2024, 卷号: 84, 期号: 5, 页码: 688-702
作者:
Wang, Hui
;
Zhang, Yanyang
;
Tian, Yu
;
Yang, Wanlin
;
Wang, Yan
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/05/07
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors
期刊论文
OAI收割
PROTEIN & CELL, 2023, 卷号: 14, 期号: 1, 页码: 17-27
作者:
Zang, Yi
;
Su, Mingbo
;
Wang, Qingxing
;
Cheng, Xi
;
Zhang, Wenru
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/03/27
high-throughput screening
SARS
CoV-2
main
papain-like
proteases
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia
期刊论文
OAI收割
CELL RESEARCH, 2022, 页码: 19
作者:
Hu, Cheng-Long
;
Chen, Bing-Yi
;
Li, Zijuan
;
Yang, Tianbiao
;
Xu, Chun-Hui
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2022/12/13