中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
大连化学物理研究所 [40]
上海药物研究所 [34]
高能物理研究所 [26]
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期刊论文 [271]
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2024 [8]
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浏览/检索结果:
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Chat-microreactor: A large-language-model-based assistant for designing continuous flow systems
期刊论文
OAI收割
CHEMICAL ENGINEERING SCIENCE, 2025, 卷号: 311
作者:
Pan, Yongqi
;
Xiao, Qinfan
;
Zhao, Fangyu
;
Li ZH(李振豪)
;
Liu, Jianyang
  |  
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2025/04/21
Flow chemistry
Microreactor
Large language models
Machine learning
Multi-phase dispersion
IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response
期刊论文
OAI收割
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2025, 卷号: 14, 期号: 1, 页码: 19
作者:
Yao, Mingyue
;
Yan, Wenzhong
;
Wang, Yafang
;
Zhao, Yu
;
Xu, Xiaowei
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/04/01
Acute myeloid leukemia
HDAC inhibitor
FLT3-ITD mutation
DNA damage response
Synergistic effect
Drug resistance
Selective Degradation of TEADs by a PROTAC Molecule Exhibited Robust Anticancer Efficacy In Vitro and In Vivo
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 25
作者:
Lu, Yuhang
;
Yan, Ziqin
;
Sun, Jiaqi
;
Wang, Chenxu
;
Xu, Lan
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/04/01
Tumor-specific delivery of clickable inhibitor for PD-L1 degradation and mitigating resistance of radioimmunotherapy
期刊论文
OAI收割
SCIENCE ADVANCES, 2024, 卷号: 10, 期号: 46, 页码: 17
作者:
Hou, Bo
;
Ye, Jiayi
;
Huang, Lujia
;
Cheng, Wenhao
;
Chen, Fangmin
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/12/16
Comparative Validation and Misclassification Diagnosis of 30-Meter Land Cover Datasets in China
期刊论文
OAI收割
REMOTE SENSING, 2024, 卷号: 16, 期号: 22, 页码: 27
作者:
Xu, Xiaolin
;
Li, Dan
;
Liu, Hongxi
;
Zhao, Guang
;
Cui, Baoshan
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/03/03
land cover maps
inconsistency evaluation
accuracy assessment
misclassification diagnosis
Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 36
作者:
Lou, Jianfeng
;
Zhou, Qianqian
;
Lyu, Xilin
;
Cen, Xinyi
;
Liu, Chen
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/08/22
Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting
β
-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 36
作者:
Zhu, Wenhua
;
Liu, Cuiting
;
Xi, Kang
;
Li, Anqi
;
Shen, Li-an
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/08/20
Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 270, 页码: 16
作者:
Lin, Zhitong
;
Liu, Chen
;
Yan, Ziqin
;
Cheng, Jing
;
Wang, Xiancheng
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2024/06/27
MDM2
p53
p21
Imidazolidinone
Apoptosis
Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-KB-inducing kinase (NIK)
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1295, 页码: 19
作者:
  |  
收藏
  |  
浏览/下载:149/0
  |  
提交时间:2023/12/08
Kinase inhibitor
NIK
NF-KB2
Indoline
COT
Cytotoxicity
Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1079-1092
作者:
Qin, Shaozhao
;
Feng, Lijian
;
Zhao, Qingyi
;
Yan, Ziqin
;
Lyu, Xilin
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2024/02/27