中国科学院机构知识库网格
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Green synthesis of 2-trifluoromethylquinoline skeletons
via
organocatalytic
N
-[(
α
-trifluoromethyl)vinyl]isatins CN bond activation
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2025, 卷号: 36, 期号: 7, 页码: 10
作者:
Ji, Cong-Bin
;
Xie, Ding-Xiong
;
Chen, Mei
;
Lan, Ye-Ying
;
Zhang, Bao-Hua
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/07/25
N-[(alpha-Trifluoromethyl)vinyl]isatins
Pfitzinger-type reaction
C-N bond cleavage
2-CF3-quinoline-4-carboxamide
2-CF3-quinoline-4-carboxylicester
Design, synthesis and bio-evaluation of 2,5-disubstituted thiazole derivatives for potential treatment of acute myeloid leukemia through targeting CDK9
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 160, 页码: 16
作者:
Chen, Sumeng
;
Huang, Jindi
;
Zhang, Shipeng
;
Zheng, Xinni
;
Chen, Hongming
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/06/23
CDK9
Inhibitor
Acute myeloid leukemia
Binding mode
Cellular mechanism
Palladium-Catalyzed Enantioselective Arylative Dearomatization of Naphthols and Phenols for Constructing Quinazoline-Containing Spirocycles
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 9
作者:
Zhang, Chiyue
;
Xu, Gaoya
;
Zhao, Wenlu
;
Li, Xutong
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/07/25
Antiproliferative activity
Catalytic asymmetric dearomatization
Palladium
Quinazoline-containing spirocycles
Three-dimensionality
Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 卷号: 147, 期号: 18, 页码: 15469-15481
作者:
Wu, Xinyuan
;
Pan, Jiayi
;
Fan, Rufeng
;
Zhang, Yiwei
;
Wang, Chao
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/06/23
Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 14
作者:
Wu, Xinyuan
;
Li, Shunyao
;
Liang, Ting
;
Yu, Qing
;
Zhang, Yiwei
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/06/23
Activity-based protein profiling data
Covalent DNA-encoded chemical library
Covalent ligand selection
Lysine-targeting covalent inhibitors
Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 卷号: 122, 期号: 14, 页码: 11
作者:
Yang, Zhenni
;
Zheng, Yueming
;
Ma, Demin
;
Wang, Long
;
Zhang, Jiatong
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/06/23
KCNQ
PIP2
ligand activation
structure
mechanism
A holistic strategy for the in-depth discrimination and authentication of 16 citrus herbs and associated commercial products based on machine learning techniques and non-targeted metabolomics
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY A, 2025, 卷号: 1745, 页码: 12
作者:
Huang, Yu-shi
;
An, Ya-ling
;
Zheng, Yue-yuan
;
Zhao, Wen-jie
;
Song, Chun-qian
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2025/04/01
Citrus herbs
Discrimination
LC-MS
Machine learning
Differential markers
Time-Dependent Regulation of Sleep-Wakefulness and Electroencephalographic Characteristics by Spontaneous Running in Male Mice
期刊论文
OAI收割
JOURNAL OF SLEEP RESEARCH, 2025, 页码: 16
作者:
Zhou, Wufang
;
Zhou, Jialin
;
Lu, Qianyu
;
Wang, Long
;
Liang, Yutao
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/05/27
delta power
spontaneous running
theta wave
voluntary exercise
Current landscape of metal-organic framework-mediated nucleic acid delivery and therapeutics
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2025, 卷号: 672, 页码: 21
作者:
Feng, Shiwei
;
Li, Yan
;
Tan, Zheng
;
Shen, Shiyang
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/04/01
Metal-organic frameworks
Nucleic acids
Nanocarrier
Drug delivery
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 9
作者:
Wang, Ze-chen
;
Zeng, Yue
;
Sun, Jin-yuan
;
Chen, Xue-qin
;
Wu, Hao-chen
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/24
deep learning
scoring function
GluN1/GluN3A receptor
N
-methyl-
D
-aspartate (NMDA) receptor
virtual screening
drug discovery