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浏览/检索结果: 共2018条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 24 作者:  Li, Na;  Wang, Linlin;  Hu, Xinyuan;  Xu, Haiyan;  Yang, Bowen   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/08/20 Voltage-gated sodium channel 1.8  Conformational restriction  Pharmacokinetic  Structure-activity relationship  Analgesic   EP240801a/XRF 240801B: An X-Ray Flash Detected by the Einstein Probe and the Implications of Its Multiband Afterglow 期刊论文  OAI收割 ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 988, 期号: 1 作者:  Jiang, Shuai-Qing;  Xu, Dong;  Hoof, Agnes P. C. van;  Lei, Wei-Hua   |  收藏  |  浏览/下载：21/0  |  提交时间：2025/07/28 Visible-Light-Controlled Lysine-Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 15 作者:  Xu, Yali;  Hu, Hao;  Ran, Yu;  Zhao, Wensi;  Guo, An-Di   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/08/20 Chemoproteomics  Molecular glue degraders  Photo-crosslinking  Protein-protein interactions  Targeted protein degradation   Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2025, 页码: 13 作者:  Li, Kun;  Zeng, Yue;  Xiong, Yi-da;  Wu, Hao-chen;  Fang, Sui   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/08/20 drug-target affinity prediction  virtual screening  contrastive learning  graph neural network  N-methyl-D-aspartate (NMDA) receptors  GluN3A subunit.   Androgens alleviate the depression-like phenotype in female mice by inhibiting AVPR1a in the hippocampal brain region 期刊论文  OAI收割 MOLECULAR MEDICINE, 2025, 卷号: 31, 期号: 1, 页码: 15 作者:  Ren, Shimin;  Wang, Xian;  Huang, Xueying;  Chen, Liyang;  Zhang, Bing   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/08/20 Androgen receptors  AVPR1a  Female  Depression  DHEA  Hippocampus   Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2025, 页码: 8 作者:  Wang, Shi-hang;  Zeng, Yue;  Yang, Hao;  Tian, Si-yuan;  Zhou, Yong-qi   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/07/25 N-methyl-D-aspartate receptors  GluN1/GluN3A  ligand-based virtual screening  scaffold hopping  deep learning  GeminiMol   Discovery of 3-(Fluoro-imidazolyl)pyridazine Derivatives as Potent STING Agonists with Antitumor Activity 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 9864-9885 作者:  Hou, Hui;  Zhou, Jingyi;  Sui, Qibang;  Zhang, Changfa;  Su, Zhaoming   |  收藏  |  浏览/下载：11/0  |  提交时间：2025/07/25 Proteogenomic characterization of non-functional clinically relevant subgroups 期刊论文  OAI收割 CANCER CELL, 2025, 卷号: 43, 期号: 4, 页码: 36 作者:  Ji, Shunrong;  Cao, Lihua;  Gao, Jing;  Du, Yang;  Ye, Zeng   |  收藏  |  浏览/下载：29/0  |  提交时间：2025/06/23 The Red Supergiant Progenitor of the Type II Supernova 2024abfl 期刊论文  OAI收割 ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 982, 期号: 2 作者:  Luo JX(罗竞霄);  Zhang LF(张力夫);  Chen, Bing-Qiu;  Cheng QY(程其原);  Guo BY(郭博洋)   |  收藏  |  浏览/下载：50/0  |  提交时间：2025/04/14 An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2025, 页码: 9 作者:  Wang, Ze-chen;  Zeng, Yue;  Sun, Jin-yuan;  Chen, Xue-qin;  Wu, Hao-chen   |  收藏  |  浏览/下载：13/0  |  提交时间：2025/04/24 deep learning  scoring function  GluN1/GluN3A receptor  N-methyl-D-aspartate (NMDA) receptor  virtual screening  drug discovery