中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [12]
金属研究所 [1]
中国科学院大学 [1]
生态环境研究中心 [1]
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OAI收割 [14]
iSwitch采集 [1]
内容类型
期刊论文 [15]
发表日期
2022 [1]
2021 [2]
2019 [4]
2017 [3]
2016 [4]
2012 [1]
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学科主题
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The difference between drainage channels and sewers in rural areas: from sewage quality to bacterial characteristics
期刊论文
OAI收割
WATER SCIENCE AND TECHNOLOGY, 2022, 页码: 1-11
作者:
Han, Yun
;
Li, Wenkai
;
Zheng, Tianlong
;
Ge, Guanghuan
;
Feng, Ke
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/02/06
bacteria
channel
collection system
rural sewage
sewer
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8194-8207
作者:
Du, Daohai
;
Xu, Dandan
;
Zhu, Licheng
;
Stazi, Giulia
;
Zwergel, Clemens
  |  
收藏
  |  
浏览/下载:96/0
  |  
提交时间:2021/08/17
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 7, 页码: 3956-3975
作者:
Zhang, Hefeng
;
Peng, Xia
;
Dai, Yang
;
Shao, Jingwei
;
Ji, Yinchun
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/06/11
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85
作者:
Zhan, Wenhu
;
Che, Jinxin
;
Xu, Lei
;
Wu, Yizhe
;
Hu, Xiaobei
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Pyrazole-thiophene derivatives
Akt inhibitor
Antitumor
Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity
期刊论文
OAI收割
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 8, 页码: 775-785
作者:
Zhu, Kongkai
;
Shao, Jingwei
;
Tao, Hongrui
;
Yan, Xue
;
Luo, Cheng
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
PRMT5 inhibitor
Anti-proliferative
Cellular target validation
Design and synthesis
Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 317-333
作者:
Shao, Jingwei
;
Zhu, Kongkai
;
Du, Daohai
;
Zhang, Yuanyuan
;
Tao, Hongrui
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
PRMT5 inhibitors
N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
Anti-tumor
Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4 alpha
期刊论文
OAI收割
THERANOSTICS, 2019, 卷号: 9, 期号: 9, 页码: 2606-2617
作者:
Zheng, Bai-Nan
;
Ding, Chen-Hong
;
Chen, Shi-Jie
;
Zhu, Kongkai
;
Shao, Jingwei
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
PRMT5
HNF4 alpha
hepatocellular carcinoma
cancer stem cells
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 页码: 128-152
作者:
Wang, Zhengyu
;
Shi, Xiaofan
;
Zhang, Huan
;
Yu, Liang
;
Cheng, Yanhua
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Type 2 diabetes mellitus
Hypoglycemia
Dyslipidemia
Glucokinase activators
N-Thiazol-2-yl-benzamides
Sandwich-structured C/C-SiC composites fabricated by electromagnetic-coupling chemical vapor infiltration
期刊论文
OAI收割
NATURE PUBLISHING GROUP, 2017, 卷号: 7, 页码: -
作者:
Hu, Chenglong
;
Hong, Wenhu
;
Xu, Xiaojing
;
Tang, Sufang
;
Du, Shanyi
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2018/01/10
Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 14, 页码: 6289-6304
作者:
Mao, Ruifeng
;
Shao, Jingwei
;
Zhu, Kongkai
;
Zhang, Yuanyuan
;
Ding, Hong
  |  
收藏
  |  
浏览/下载:100/0
  |  
提交时间:2019/01/08