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浏览/检索结果: 共214条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Low-Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells 期刊论文  OAI收割 ADVANCED SCIENCE, 2024, 页码: 17 作者:  Pu, Congying;  Li, Yize;  Fu, Yixian;  Yan, Yiyang;  Tao, Siyao   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/02/27 AIM2 inflammasome  chemotherapy  gut microbiome  ileal epithelial cells  immune checkpoint blockade  lactobacillus  segmented filamentous bacterium   LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter 期刊论文  OAI收割 BMC CANCER, 2023, 卷号: 23, 期号: 1, 页码: 20 作者:  Ren, Ganglin;  Li, Hongyan;  Hong, Dan;  Hu, Fangyu;  Jin, Rongjia   |  收藏  |  浏览/下载：6/0  |  提交时间：2023/12/08 LINC00955  Colorectal cancer  Cell cycle  CDK2  PHIP  Sp1   Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 15 作者:  Mei, Lianghe;  Xu, Lansong;  Wu, Sanan;  Wang, Yafang;  Xu, Chao   |  收藏  |  浏览/下载：39/0  |  提交时间：2023/10/17 Betulinic acid  ROR & gamma  Target identification  Rationale structure optimization  Anti-tumor effects  antagonists   Synthesis, and biological evaluation of EGFR/HER2-NAMPT conjugates for tumor treatment 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2023, 页码: 20 作者:  Ding, Mengyuan;  Shen, Qianqian;  Lu, Wei;  Zhu, Shulei   |  收藏  |  浏览/下载：62/0  |  提交时间：2023/10/17 EGFR  HER2  NAMPT  Resistance  Selectivity  Molecular docking   Discovery of HyT-Based Degraders of CDK9-Cyclin T1 Complex 期刊论文  OAI收割 CHEMISTRY & BIODIVERSITY, 2023, 页码: 10 作者:  Lin, Rongkun;  Yang, Jie;  Liu, Ting;  Wang, Mingyu;  Ke, Chongrong   |  收藏  |  浏览/下载：20/0  |  提交时间：2023/10/17 CDK9  cyclin T1  degrader  hydrophobic tag  protein degradation   Discovery of new small molecule inhibitors of the BPTF bromodomain 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 134, 页码: 106453 作者:  Liang, Xiaochen;  Cao, Yu;  Duan, Zhe;  Wang, Mingchen;  Zhang, Naixia   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27 BPTF bromodomain  BPTF inhibitors  HTRF  c-Myc   Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 7, 页码: 4932-4951 作者:  Wang, Mingyu;  Lin, Rongkun;  Li, Jiacheng;  Suo, Yuying;  Gao, Jing   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17 Multi-omics profiling of PC-3 cells reveals bufadienolides-induced lipid metabolic remodeling by regulating long-chain lipids synthesis and hydrolysis 期刊论文  OAI收割 METABOLOMICS, 2023, 卷号: 19, 期号: 2, 页码: 13 作者:  Zhang, Rong;  Zhang, Zijia;  Wu, Wenyong;  Shi, Jingying;  Berk, Entezar   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/04/10 Bufadienolides  Prostate cancer  Lipidomics  Transcriptomics  ELOVL6  PLD1   Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 18 作者:  Tang, Hairong;  Yu, Aisong;  Xing, Li;  Chen, Xiaoyu;  Ding, Huaqian   |  收藏  |  浏览/下载：16/0  |  提交时间：2023/04/10 Design, synthesis and biological evaluation of KRASG12C-PROTACs 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14 作者:  Zhang, Xiaoyi;  Zhao, Tong;  Sun, Minghao;  Li, Pei;  Lai, Mengzhen   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/04/10 KRASG12C  PROTAC  Covalent inhibitors  Structure-activity relationships (SARs)  Anticancer