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上海药物研究所 [54]
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Fluorescence-Coupled Ubiquitination Assay as a High-Throughput Screening Strategy for Novel Cereblon Degraders
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 10111-10127
作者:
Deng, Yanan
;
Yang, Shiling
;
Xu, Hesong
;
Ding, Xiyao
;
Xu, Ying
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/06/23
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Pathfinding Pulsar Observations with the CVN Incorporating the FAST
期刊论文
OAI收割
CHINESE PHYSICS LETTERS, 2024, 卷号: 41, 期号: 11, 页码: 117501
作者:
Yan, Zhen
;
Shen, Zhiqiang
;
Jiang, Peng
;
Zhang, Bo
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/12/06
Structure-Based Drug Design of 2-Amino-[1,1′-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of
CCNE1
-Amplified Breast Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21
作者:
Wang, Chaofan
;
Fang, Yan
;
Zhou, Ziqin
;
Liu, Zhuoheng
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/09/26
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 期号: 1, 页码: 17
作者:
Zhang, Tao
;
Pan, Zilu
;
Gao, Jing
;
Wu, Qingqing
;
Bai, Gang
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2024/10/21
Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 36
作者:
Lou, Jianfeng
;
Zhou, Qianqian
;
Lyu, Xilin
;
Cen, Xinyi
;
Liu, Chen
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/08/22
GFPBW1, a β-glucan from
Grifola frondosa
as vaccine adjuvant: APCs activation and maturation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
He, Xiang
;
Lu, Jiang-ling
;
Liao, Wen-feng
;
Long, Yi-ru
;
Zhang, Xing
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/08/20
cancer vaccine
adjuvant
granola frondose polysaccharide
GFPBW1
beta-glucan
Mapping Brain Synergy Dysfunction in Schizophrenia: Understanding Individual Differences and Underlying Molecular Mechanisms
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 16
作者:
Ding, Chaoyue
;
Li, Ang
;
Xie, Sangma
;
Tian, Xiaohan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/09/09
hierarchical Bayesian model
information interactions
latent factors
neurodynamics
schizophrenia
synergy dysfunction
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Song, Pei-ran
;
Wan, Zhi-peng
;
Huang, Ge-ge
;
Song, Zi-lan
;
Zhang, Tao
  |  
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2024/07/12
diffuse large B-cell lymphoma
BTK inhibitors
drug resistance
BTK C481F
BTK A428D
SYHA1813
Pharmacokinetics, mass balance, and metabolism of [
14
C]envonalkib (TQ-B3139), a novel ALK tyrosine kinase inhibitor, in healthy Chinese subjects
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2024, 页码: 11
作者:
Ma, Sheng
;
Wang, Xin
;
Yan, Shu
;
Miao, Liyan
;
Wan, Xiaojing
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/05/07
Envonalkib
TQ-B3139
Pharmacokinetics
Mass balance
Excretion
Metabolism