中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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心理研究所 [9]
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期刊论文 [60]
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Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1318, 页码: 13
作者:
Tang, Mingze
;
Zhou, Xuan
;
Shen, Qianqian
;
Fang, Chen
;
Peng, Xia
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/08/22
Receptor -interacting protein kinase 1
Histone deacetylases
Inhibitor
Molecular dynamics (MD) simulation
ADMET analysis
Cross-ancestry genome-wide association studies of brain imaging phenotypes
期刊论文
OAI收割
NATURE GENETICS, 2024, 页码: 31
作者:
Fu, Jilian
;
Zhang, Quan
;
Wang, Jianhua
;
Wang, Meiyun
;
Zhang, Bing
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/06/29
Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17
作者:
Lan, Yaohan
;
Peng, Xia
;
Ji, Yinchun
;
Su, Yi
;
Duan, Wenhu
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2024/02/27
AXL inhibitor
In vivo antitumor efficacy
6-Naphthyridin-4-one derivatives
Scaffold hopping
Structure-based drug design
Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 1829
作者:
Zhao,Qi
;
Dai,Man-Yun
;
Huang,Ruo-Yue
;
Duan,Jing-Yi
;
Zhang,Ting
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/05/09
FATTY LIVER-DISEASE
INDUCED CHOLESTASIS
STELLATE CELLS
PROBIOTICS
PROTECTS
INFLAMMATION
APOPTOSIS
OBESITY
AXIS
Delphinieae flowers originated from the rewiring of interactions between duplicated and diversified floral organ identity and symmetry genes
期刊论文
OAI收割
PLANT CELL, 2023, 卷号: 35, 期号: 3, 页码: 994-1012
作者:
Zhao, Huiqi
;
Liao, Hong
;
Li, Shuixian
;
Zhang, Rui
;
Dai, Jing
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/07
Generation and application of a novel high-throughput detection based on RPA-CRISPR technique to sensitively monitor pathogenic microorganisms in the environment
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2022, 卷号: 838, 页码: 9
作者:
Liu, Li
;
Duan, Jin-Jing
;
Wei, Xing-Yi
;
Hu, Huan
;
Wang, Yuan-Bo
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2022/08/22
Nucleic acid detection
CRISPR
Cas12a
Staphylococcus aureus
RPA-CRISPR
Cas12a-FQ
Cas12a-LFA
Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
He, Yi-fei
;
Liu, Yin
;
Yu, Jing-hua
;
Cheng, Huan
;
Odilov, Abdullajon
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/08/16
TPN171
[C-14]TPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder
期刊论文
OAI收割
TRANSLATIONAL PSYCHIATRY, 2022, 卷号: 12, 期号: 1, 页码: 9
作者:
Ding, Yu-Dan
;
Chen, Xiao
;
Chen, Zuo-Bing
;
Li, Le
;
Li, Xue-Ying
  |  
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2022/07/18
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 9
作者:
Qian, Hong-jie
;
Wang, Yu
;
Zhang, Meng-qi
;
Xie, Yuan-chao
;
Wu, Qing-qing
  |  
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2022/06/15
VV116
nucleoside analog
SARS-CoV-2
safety
pharmacokinetics
healthy subjects
Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022
期刊论文
OAI收割
NUCLEIC ACIDS RESEARCH, 2022, 卷号: 50, 期号: D1, 页码: D27-D38
作者:
Xue, Yongbiao
;
Bao, Yiming
;
Zhang Zhang
;
Zhao, Wenming
;
Xiao, Jingfa
  |  
收藏
  |  
浏览/下载:119/0
  |  
提交时间:2022/04/02