机构

• 上海药物研究所 [37]
• 广州生物医药与健康研... [2]
• 寒区旱区环境与工程研... [1]
• 上海有机化学研究所 [1]
• 动物研究所 [1]
• 兰州化学物理研究所 [1]
• 更多

采集方式

• OAI收割 [42]
• iSwitch采集 [1]

内容类型

• 期刊论文 [43]

发表日期

• 2024 [1]
• 2023 [3]
• 2022 [3]
• 2021 [3]
• 2020 [1]
• 2019 [4]
• 更多

学科主题

• Chemistry [3]
• Pharmacolo... [3]
• 生命有机化学 [1]

筛选

浏览/检索结果: 共43条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17 作者:  Lan, Yaohan;  Peng, Xia;  Ji, Yinchun;  Su, Yi;  Duan, Wenhu   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/02/27 AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design   Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 18 作者:  Ren, Pengxuan;  Li, Hui;  Nie, Tianqing;  Jian, Xiaoqin;  Yu, Changyue   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 Discovery of pyrido[4,3-d]pyrimidinone derivatives as novel Wee1 inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 87, 页码: 12 作者:  Ye, Qingqing;  Ma, Jingkun;  Wang, Peipei;  Wang, Chang;  Sun, Mei   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 Wee1 inhibitor  Scaffold hopping   Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 247, 页码: 115034 作者:  Song, Shukai;  Tang, Haotian;  Ran, Ting;  Fang, Feng;  Tong, Linjiang   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/03/27 SyntaLinker  Generative modelling  TBK1 inhibitor  pyrrolo[2  3-d]pyrimidine  Structure-activity relationship   Design, synthesis and biological evaluation of novel dihydrobenzodioxine derivatives as HBV capsid protein inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 12 作者:  Liu, Linyue;  Li, Chuanju;  Xie, Yong;  Zhang, Lei;  Chen, Yunfu   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/10/17 HBV  Capsid protein inhibitors  Pharmacophore hybrid  Scaffold hopping  HepAD38 cells   Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238, 页码: 16 作者:  Niu, Jing;  Bai, Hudagula;  Li, Zizhou;  Gao, Yuzhe;  Zhang, Yan   |  收藏  |  浏览/下载：23/0  |  提交时间：2022/08/16 STING  cGAS  Non-cyclic dinucleotides (non-CDNs)  Systemic administration  Antitumor immunotherapy   Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2022, 卷号: 124, 页码: 15 作者:  Liu, Ruiqi;  Yang, Hong;  Chen, Zonglong;  Zhou, Kaixin;  Shi, Qiongyu   |  收藏  |  浏览/下载：37/0  |  提交时间：2022/08/16 Epigenetics  p300  CBP  Bromodomain inhibitors  CCS1477   Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663 作者:  Han, Xu;  Song, Ning;  Saidahmatov, Abdusaid;  Wang, Peipei;  Wang, Yong   |  收藏  |  浏览/下载：58/0  |  提交时间：2021/12/16 Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole Scaffold 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 9, 页码: 6161-6178 作者:  Xiong, Chaodong;  Zhou, Lina;  Tan, Jing;  Song, Shanshan;  Bao, Xubin   |  收藏  |  浏览/下载：19/0  |  提交时间：2021/08/17 Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS(G12C) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 213, 页码: 17 作者:  Xiao, Xuanzheng;  Lai, Mengzhen;  Song, Zilan;  Geng, Meiyu;  Ding, Jian   |  收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24 KRAS  Covalent inhibitor  Pyridopyrimidinone  Antiproliferative effect  Scaffold hopping