机构

• 上海药物研究所 [10]

采集方式

• OAI收割 [10]

内容类型

• 期刊论文 [10]

发表日期

• 2024 [3]
• 2023 [3]
• 2022 [2]
• 2020 [1]
• 2019 [1]

学科主题

筛选

浏览/检索结果: 共10条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Potency Prediction of Covalent Inhibitors against SARS-CoV-2 3CL-like Protease and Multiple Mutants by Multiscale Simulations 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 卷号: 64, 期号: 24, 页码: 9501-9516 作者:  Xiong, Muya;  Nie, Tianqing;  Li, Zhewen;  Hu, Meiyi;  Su, Haixia   |  收藏  |  浏览/下载：4/0  |  提交时间：2025/01/06 Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Nonstructural Protein Inhibitors 期刊论文  OAI收割 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 页码: 14 作者:  Wang, Xudong;  Xiong, Liwei;  Zhu, Ying;  Liu, Sixiu;  Zhao, Wenfeng   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/12/25 Chemical Space Profiling of SARS-CoV-2 PLpro Using DNA-Encoded Focused Libraries 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2024, 页码: 10 作者:  Wang, Xudong;  Zhu, Ying;  Zhao, Qingyi;  Lu, Weiwei;  Xu, Yechun   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/05/07 DNA-Encoded Focused Libraries (DEFLs)  SARS-CoV-2  Papain-like Protease  Library Design  ProteinInhibitors   Discovery, SAR Study of GST Inhibitors from a Novel Quinazolin-4(1H)-one Focused DNA-Encoded Library 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 15 作者:  Wen, Xin;  Zhang, Minmin;  Duan, Zhiqiang;  Suo, Yanrui;  Lu, Weiwei   |  收藏  |  浏览/下载：47/0  |  提交时间：2023/10/17 Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 10, 页码: 15 作者:  Wang, Qian;  Chen, Guofeng;  He, Jian;  Li, Jiameng;  Xiong, Muya   |  收藏  |  浏览/下载：33/0  |  提交时间：2023/10/17 SARS-CoV-2  papain-like protease  covalent inhibitor  co-crystal structure  in vitro assay   Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches 期刊论文  OAI收割 CHEMICAL SCIENCE, 2023, 卷号: 14, 期号: 18, 页码: 4681-4696 作者:  Shao, Qiang;  Xiong, Muya;  Li, Jiameng;  Hu, Hangchen;  Su, Haixia   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/03/27 Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 页码: 10 作者:  Hu, Hangchen;  Wang, Qian;  Su, Haixia;  Shao, Qiang;  Zhao, Wenfeng   |  收藏  |  浏览/下载：25/0  |  提交时间：2023/04/10 Allosteric Modulator  Cysteine 270  Drug Design  Papain-Like Protease  SARS-CoV-2   Structure-based design of a novel inhibitor of the ZIKA virus NS2B/ NS3 protease 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 7 作者:  Xiong, Yanchao;  Cheng, Fei;  Zhang, Junyi;  Su, Haixia;  Hu, Hangchen   |  收藏  |  浏览/下载：37/0  |  提交时间：2022/11/11 Zika virus  Fragment -based hit screening  Protein -inhibitor interactions  NS2B  NS3 protease  Crystal structure   Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 13, 页码: 7052-7065 作者:  Huang, Fubao;  Hu, Hangchen;  Wang, Kai;  Peng, Chengyuan;  Xu, Wenwei   |  收藏  |  浏览/下载：66/0  |  提交时间：2020/12/24 Structure-Based Survey of the Binding Modes of BACE1 Inhibitors 期刊论文  OAI收割 ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 2, 页码: 880-889 作者:  Hu, Hangchen;  Chen, Zhaoqiang;  Xu, Xiang;  Xuo, Yechun   |  收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01 BACE1  Alzheimer's disease  inhibitor  ligand binding mode  subsite  substructure