中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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化学研究所 [176]
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Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 10
作者:
Zhang, Chun
;
Yan, Xue
;
Gao, Li-Xin
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
Imidazo[2,1-b][1,3,4]thiadiazole
Inhibitory activities
Fluorescence imaging
Zebrafish
SHP2
Guiding precision medicine strategy for intravenous ginsenosides via pharmacokinetic-informed bioinformatic approaches: a study on XueShuanTong
期刊论文
OAI收割
PHYTOMEDICINE, 2025, 卷号: 143, 页码: 18
作者:
Jia, Wei-Wei
;
Tian, Nan-Nan
;
Song, Zi-Jing
;
Lan, Xiao-Fang
;
Yang, Xi-He
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Precision medicine
Physiologically based pharmacokinetic model
Ginsenoside
Albumin-facilitated dissociation
Drug interaction
Drug transporter
Hepatic impairment
Metabolomic and evolutionary integration unveils medicinal potential in six
Corydalis
species
期刊论文
OAI收割
MOLECULAR HORTICULTURE, 2025, 卷号: 5, 期号: 1, 页码: 14
作者:
Gao, Yun
;
Zhou, Xiangyu
;
Yan, Mengxiao
;
Wang, Zhengwei
;
Zhong, Xin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Corydalis
genus
Benzylisoquinoline alkaloids (BIAs)
Evolutionary analysis
Metabolomics
Medicinal resources
Risk assessment of CYP3A induction by ginsenoside's metabolites from oral Panax notoginseng (sanqi) extract
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 349, 页码: 11
作者:
Deng, Yang
;
Du, Jing
;
He, Xin
;
Dong, Yan-Xi
;
Wang, Xiao-Lei
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Panax notoginseng
Ginsenoside
Intestinal microbiota
CYP3A induction
Drug interaction
Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism
期刊论文
OAI收割
CELL METABOLISM, 2025, 卷号: 37, 期号: 5, 页码: 32
作者:
Jiang, Jie
;
Gao, Yuqing
;
Wang, Jiang
;
Huang, Yan
;
Yang, Rong
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
Discovery of multi-chitinase inhibitors cinnamyl thiazolidinone compounds as candidates for insect growth regulators via ligand-based optimization strategies
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 卷号: 306, 页码: 14
作者:
Jiang, Zhiyang
;
Shi, Dongmei
;
Fu, Haoyu
;
Li, Yan
;
Zou, Renxuan
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/05/27
Multi-chitinase inhibitor
Cinnamaldehyde compounds
Thiazolidinone compounds
Ligand-based optimization
Insect growth regulators (IGRs)
Exploring Origin-Dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases Through Intersectional Genetics
期刊论文
OAI收割
CIRCULATION, 2025, 卷号: 151, 期号: 17, 页码: 1248-1267
作者:
Han, Ximeng
;
Li, Yi
;
Wang, Enci
;
Zhu, Huan
;
Huang, Xiuzhen
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/06/23
aortic diseases
developmental origin
lineage tracing
smooth muscle cell
TGF-beta
Glabridin as a selective Kv2.1 inhibitor ameliorates DPN pathology by disrupting the Aβ/Kv2.1/JNK/NF-κB/NLRP3/p-Tau pathway
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 17
作者:
Xu, Jia-wen
;
Ma, Lin
;
Xiang, Yu
;
Dai, Meng-qing
;
Li, Qiu-hui
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/05/27
diabetic peripheral neuropathy
glabridin
Kv2.1
dorsal root ganglia
Schwann cells
A beta/Kv2.1/NLRP3/p-Tau axis
Accumulation of lipophilic and proteinophilic halogenated organic pollutants (HOPs) in the different types of feathers of laying hens
期刊论文
OAI收割
JOURNAL OF HAZARDOUS MATERIALS, 2025, 卷号: 486, 页码: 9
作者:
Chen, Xi
;
Luo, Xiao-Jun
;
Feng, Qun-Jie
;
Liu, Yu
;
Dai, Jun-Zhe
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2025/04/03
Feathers
Halogenated organic pollutants
Laying hens
Bioaccumulation
Microplastic-Induced Alterations in Soil Aggregate-Associated Carbon Stabilization Pathways: Evidence from δ13C Signature Analysis
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2025, 卷号: 59, 期号: 11, 页码: 5545-5555
作者:
Li, Yanpei
;
Yan, Qing
;
Zou, Chuningrui
;
Li, Xia
;
Wang, Jiao
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2025/04/21
microplastics
soil aggregate
delta C-13 signature
aggregate-associated organic carbon