机构

• 上海药物研究所 [45]
• 金属研究所 [2]

采集方式

• OAI收割 [47]

内容类型

• 期刊论文 [46]
• 会议论文 [1]

发表日期

• 2024 [6]
• 2023 [3]
• 2022 [2]
• 2021 [3]
• 2020 [2]
• 2019 [3]
• 更多

学科主题

筛选

浏览/检索结果: 共47条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors 期刊论文  OAI收割 JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1318, 页码: 13 作者:  Tang, Mingze;  Zhou, Xuan;  Shen, Qianqian   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/08/22 Receptor -interacting protein kinase 1  Histone deacetylases  Inhibitor  Molecular dynamics (MD) simulation  ADMET analysis   Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives as necroptosis inhibitors 期刊论文  OAI收割 RSC MEDICINAL CHEMISTRY, 2024, 卷号: 15, 期号: 7, 页码: 2514-2526 作者:  Jin, Zechen;  Dai, Yang;  Ji, Yinchun;  Peng, Xia;  Duan, Wenhu   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/08/20 Discovery and optimization of 3-(indolin-5-yloxy)pyridin-2-amine derivatives as potent necroptosis inhibitors 期刊论文  OAI收割 ARCHIV DER PHARMAZIE, 2024, 页码: 21 作者:  Lan, Yaohan;  Ji, Yinchun;  Peng, Xia;  Duan, Wenhu;  Geng, Meiyu   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/08/22 autoimmune disease  necroptosis inhibitor  pharmacokinetic profile  receptor interacting protein kinase 1 (RIPK1)  structural optimization   Remodeling tumor-associated macrophage for anti-cancer effects by rational design of irreversible inhibition of mitogen-activated protein kinase-activated protein kinase 2 期刊论文  OAI收割 MEDCOMM, 2024, 卷号: 5, 期号: 7, 页码: e634 作者:  Wang, Danyi;  Sun, Deqiao;  Wang, Xiaoyan;  Peng, Xia;  Ji, Yinchun   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/04 anti-tumor  irreversible inhibitor  kinase  macrophagemitogen-activated protein kinase-activated protein kinase 2 (MK2)   Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17 作者:  Lan, Yaohan;  Peng, Xia   |  收藏  |  浏览/下载：31/0  |  提交时间：2024/02/27 AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design   Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1168-1183 作者:  Xu, Zichao;  Peng, Xia;  Zhang, Renjie;  Ji, Yinchun;  You, Mengke   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/02/27 Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao   |  收藏  |  浏览/下载：27/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide   Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3226-3249 作者:  Li, Chunpu;  Dai, Yang;  Kong, Xiangtai;  Wang, Bao;  Peng, Xia   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/03/27 Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors 期刊论文  OAI收割 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023, 卷号: 38, 期号: 1, 页码: 282-293 作者:  Fan, Tiantian;  Ji, Yinchun;  Chen, Danqi;  Peng, Xia;  Ai, Jing   |  收藏  |  浏览/下载：26/0  |  提交时间：2023/04/10 RIPK2 inhibitor  NOD  immunity  inflammation   Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15 作者:  Zhan, Zhengsheng;  Ji, Yinchun;  Su, Haixia;  Fang, Chen;  Peng, Xia   |  收藏  |  浏览/下载：53/0  |  提交时间：2023/04/10