机构

• 上海药物研究所 [15]

采集方式

• OAI收割 [15]

内容类型

• 期刊论文 [14]
• 会议论文 [1]

发表日期

• 2023 [2]
• 2022 [2]
• 2021 [1]
• 2020 [1]
• 2019 [2]
• 2018 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共15条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序题名升序题名降序作者升序作者降序发表日期升序发表日期降序 Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764 作者:  Liu, Yingqiang;  Zhan, Zhengsheng;  Kang, Zhuang;  Li, Mengyuan;  Lv, Yongcong   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/01/26 Small molecule inhibitor  Tumor microenvironment  Immune-checkpoint  immune-deficient mouse models  including temozolomide (TMZ) insensitive tumors. Notably   Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2023, 页码: 10 作者:  Zhou, Rongyao;  Wang, Xiyuan;  Zhang, Deqiang;  Zhan, Zhengsheng;  Duan, Wenhu   |  收藏  |  浏览/下载：6/0  |  提交时间：2023/12/08 STING  CDN  Benzo[b]thiophene-2-carboxamide  Cellular activity   Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15 作者:  Zhan, Zhengsheng;  Ji, Yinchun;  Su, Haixia;  Fang, Chen;  Peng, Xia   |  收藏  |  浏览/下载：32/0  |  提交时间：2023/04/10 Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation 期刊论文  OAI收割 CELL DISCOVERY, 2022, 卷号: 8, 期号: 1, 页码: 17 作者:  Xie, Zuoquan;  Wang, Zhen;  Fan, Fengying;  Zhou, Jinpei;  Hu, Zhaoxue   |  收藏  |  浏览/下载：22/0  |  提交时间：2023/04/10 Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18 作者:  Xu, Dandan;  Sun, Deqiao;  Wang, Wei;  Peng, Xia;  Zhan, Zhengsheng   |  收藏  |  浏览/下载：38/0  |  提交时间：2021/08/17 Axl  Cancer  Inhibitor  Pyrrolo[2,3-d]pyrimidine   Synthesis of triazolotriazine derivatives as c-Met inhibitors 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2020, 页码: 8 作者:  Guo, Yuting;  Peng, Xia;  Ji, Yinchun;  Zhang, Yitong;  Ding, Jian   |  收藏  |  浏览/下载：39/0  |  提交时间：2020/12/24 Receptor tyrosine kinase  c-Met  Triazolotriazine  SAR  Cellular potency   fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85 作者:  Zhan, Wenhu;  Che, Jinxin;  Xu, Lei;  Wu, Yizhe;  Hu, Xiaobei   |  收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 Pyrazole-thiophene derivatives  Akt inhibitor  Antitumor   Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288 作者:  Dong, Xiaowu;  Zhan, Wenhu;  Zhao, Mengting;  Che, Jinxin;  Dai, Xiaoyang   |  收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01 Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles 期刊论文  OAI收割 CHEMICAL RESEARCH IN TOXICOLOGY, 2018, 卷号: 31, 期号: 11, 页码: 1213-1218 作者:  Zhan, Zhengsheng;  Peng, Xia;  Sun, Yiming;  Ai, Jing;  Duan, Wenhu   |  收藏  |  浏览/下载：23/0  |  提交时间：2019/01/08 Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 117, 页码: 47-58 作者:  Zhan, Wenhu;  Xu, Lei;  Dong, Xiaowu;  Dong, Jun;  Yi, Xiao   |  收藏  |  浏览/下载：13/0  |  提交时间：2019/01/08 Akt1 inhibitor  Synthesis  Cytotoxicity  Molecular docking  Cancer