中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [38]
昆明植物研究所 [30]
半导体研究所 [27]
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期刊论文 [331]
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Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Patients With Mild or Moderate Hepatic Impairment Versus Participants With Normal Hepatic Function: A Phase I Study
期刊论文
OAI收割
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 7
作者:
Zhou, Jing
;
Zhang, Hong
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/06/23
hepatic impairment
pharmacokinetics
phosphodiesterase-5 inhibitor
TPN171
Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7 (8H)-one derivatives as potent USP1 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 275, 页码: 18
作者:
Li, Hongrui
;
Liu, Ben-Jin
;
Xu, Jiahao
;
Song, Shan-Shan
;
Ba, Ruixian
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/08/22
USP1 inhibitor
Structure -activity relationships
Olaparib-resistant cell
Transcriptomic decoding of regional cortical vulnerability to major depressive disorder
期刊论文
OAI收割
COMMUNICATIONS BIOLOGY, 2024, 卷号: 7, 期号: 1, 页码: 12
作者:
Zhu, Jiajia
;
Chen, Xiao
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/09/10
Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2024, 卷号: 223, 页码: 17
作者:
Zhang, Qian
;
Wu, Qian
;
Huan, Xia-Juan
;
Song, Shan -Shan
;
Bao, Xu-Bin
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2024/06/27
BET inhibitor
NAE inhibitor
BIM
Apoptosis
Combination therapy
Gender differences in the association between anxiety symptoms and thyroid hormones in young patients with first-episode and drug na & iuml;ve major depressive disorder
期刊论文
OAI收割
FRONTIERS IN PSYCHIATRY, 2023, 卷号: 14, 页码: 9
作者:
Zhao, Ying
;
Liu, Jia Cheng
;
Yu, Feng
;
Yang, Li Ying
;
Kang, Chuan Yi
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/15
major depressive disorder
anxiety
young
risk factor
gender differences
A longitudinal resource for population neuroscience of school-age children and adolescents in China
期刊论文
OAI收割
SCIENTIFIC DATA, 2023, 卷号: 10, 期号: 1, 页码: 24
作者:
Fan, Xue-Ru
;
Wang, Yin-Shan
;
Chang, Da
;
Yang, Ning
;
Rong, Meng-Jie
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2023/12/11
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
期刊论文
OAI收割
EMBO MOLECULAR MEDICINE, 2023, 页码: 24
作者:
Wang, Li-Min
;
Wang, Pingyuan
;
Chen, Xiao-Min
;
Yang, Hui
;
Song, Shan-Shan
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2023/04/10
homologous recombination repair
olaparib-resistant
PARP inhibitor
PARP7
type I interferons
A study on the prevalence and related factors of frailty and pre-frailty in the older population with hypertension in China: A national cross-sectional study
期刊论文
OAI收割
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2023, 卷号: 9, 页码: 13
作者:
Zeng, Xue-zhai
;
Jia, Na
;
Meng, Ling-bing
;
Shi, Jing
;
Li, Ying-ying
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2023/02/27
older adults
hypertension
frailty
pre-frailty
related factors
prevalence
ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 22, 页码: e2220148120
作者:
Zhou,Gui-Feng
;
Tang,Jing
;
Ma,Yuan-Lin
;
Fu,Xian
;
Liu,Jun-Yan
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/05/09
conophylline
ARL6IP1
5'UTR
FXR1
BACE1 translation
AMYLOID PRECURSOR PROTEIN
A-BETA
TRANSGENIC MICE
MOUSE MODEL
NEURODEGENERATION
EXPRESSION
REDUCTION
MEMBRANE
MEMORY
ER
Genome-wide signatures of the geographic expansion and breeding of soybean
期刊论文
OAI收割
SCIENCE CHINA-LIFE SCIENCES, 2023, 卷号: 66, 期号: 2, 页码: 350-365
作者:
Li, Ying-Hui
;
Qin, Chao
;
Wang, Li
;
Jiao, Chengzhi
;
Hong, Huilong
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2024/03/07
soybean
adaptation
introgression
flowering time
breeding