中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Discovery of pyrrolo[2,3-d]pyrimidine derivatives as novel FLT3/ IRAK4 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 23
作者:
Yuan, Haibin
;
Gao, Yue
;
Wang, Peipei
;
Dong, Xiaowu
;
Li, Jia
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
AML
FLT3/IRAK4 inhibitor
Pyrrolo [2,3-d] pyrimidine
Acquired resistance
Adaptive resistance
Effect of hydrogen ion irradiation on the mechanical properties of thermally aged Z3CN20.09M duplex stainless steel
期刊论文
OAI收割
VACUUM, 2025, 卷号: 231, 页码: 113757
作者:
Lei, Penghui
;
Jiang, Ni
;
Hao JN(郝剑楠)
;
Peng Q(彭庆)
;
Qi, Pan
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2024/12/02
Z3CN20.09M duplex alloy
Hydrogen ions irradiation
Nanohardness
TEM in-situ tensile test
Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CL
pro
inhibitors against SARS-CoV-2
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 11
作者:
Guma, Samuel Desta
;
Song, Kang
;
Sun, Haiguo
;
Yang, Lei
;
Zhou, Zhaoyin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
SARS-CoV-2
3CL(pro) inhibitors
Thioamide derivatives
Spiropyrrolidine derivatives
Nirmatrelvir
HCoV-OC43
Antiviral
Metabolic stability
A novel heterogeneous CPU/GPGPU-accelerated 3D CDEM and its application to modeling deep roadway excavation
期刊论文
OAI收割
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS, 2025, 卷号: 177, 页码: 21
作者:
Huang, Junguang
;
Zhang, Yiming
;
Feng C(冯春)
;
Hu HN(胡桓宁)
;
Wen, Minjie
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/05/19
Roadway excavation
3D continuous-discontinuous
Heterogeneous parallel CPU/GPGPU
High-performance computing
Cryogenic 3D printing of damage tolerant hierarchical porous ceramics
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF EXTREME MANUFACTURING, 2025, 卷号: 7, 期号: 4, 页码: 11
作者:
Zhu, Zheng
;
Gao, Dandan
;
Huang, Zhuo
;
Chang, Wei
;
Wu, Bin
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2025/04/27
hierarchical structure
bioinspired designs
energy absorption
damage tolerance
3D printing
Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 10
作者:
Zhang, Chun
;
Yan, Xue
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Cao, Qing
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
Imidazo[2,1-b][1,3,4]thiadiazole
Inhibitory activities
Fluorescence imaging
Zebrafish
SHP2
Synthesis, photophysical properties and fluorescent application of novel [1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one derivatives
期刊论文
OAI收割
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2025, 卷号: 464, 页码: 11
作者:
Gan, Suya
;
Gao, Li-Xin
;
Cao, Zitong
;
Zhang, Chun
;
Fu, Yiqiu
  |  
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2025/04/01
[1
4]triazolo[1
5-a]pyrimidin-7(4H)-one
derivatives
Fluorescence properties
Fe 3+ions
A simple and efficient three-dimensional spring element model for pore seepage problems
期刊论文
OAI收割
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS, 2025, 卷号: 176, 页码: 12
作者:
Li, Jing
;
Zhu XG(朱心广)
;
Feng C(冯春)
;
Wen, Minjie
;
Zhang, Yiming
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/05/19
Three-Dimensional Seepage Spring Element
Method (3D-SSEM)
Local coordinate system
Pore seepage
Pore-solid coupled seepage
Computational efficiency
Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 122, 页码: 19
作者:
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/05/27
Innate immunity response
SARS-CoV-2 3CLpro
PLpro
EV71 3Cpro
2Apro
Viral protease inhibitor
Green synthesis of 2-trifluoromethylquinoline skeletons
via
organocatalytic
N
-[(
α
-trifluoromethyl)vinyl]isatins CN bond activation
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2025, 卷号: 36, 期号: 7, 页码: 10
作者:
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2025/07/25
N-[(alpha-Trifluoromethyl)vinyl]isatins
Pfitzinger-type reaction
C-N bond cleavage
2-CF3-quinoline-4-carboxamide
2-CF3-quinoline-4-carboxylicester