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Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 10
作者:
Zhang, Chun
;
Yan, Xue
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Cao, Qing
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2025/08/20
Imidazo[2,1-b][1,3,4]thiadiazole
Inhibitory activities
Fluorescence imaging
Zebrafish
SHP2
Synthesis, photophysical properties and fluorescent application of novel [1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one derivatives
期刊论文
OAI收割
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2025, 卷号: 464, 页码: 11
作者:
Gan, Suya
;
Gao, Li-Xin
;
Cao, Zitong
;
Zhang, Chun
;
Fu, Yiqiu
  |  
收藏
  |  
浏览/下载:111/0
  |  
提交时间:2025/04/01
[1
4]triazolo[1
5-a]pyrimidin-7(4H)-one
derivatives
Fluorescence properties
Fe 3+ions
Monocyclic and polycyclic polyprenylated acylphloroglucinols with anti-steatohepatitis effect from the pericarps of
Garcinia
multiflora
期刊论文
OAI收割
FITOTERAPIA, 2025, 卷号: 183, 页码: 9
作者:
Luo, Huijuan
;
Cao, Jun
;
Zhang, Yujia
;
Dou, Hao
;
Liang, Xu
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2025/05/27
Garcinia multiflora
MPAPs
PPAPs
IL-1 beta
NLRP3
Steatohepatitis
Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 8
作者:
Wang, Shi-hang
;
Zeng, Yue
;
Yang, Hao
;
Tian, Si-yuan
;
Zhou, Yong-qi
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2025/07/25
N
-methyl-
D
-aspartate receptors
GluN1/GluN3A
ligand-based virtual screening
scaffold hopping
deep learning
GeminiMol
Dehydrotrametenolic acid methyl ester, a triterpenoid of
Poria cocos
, alleviates non-alcoholic steatohepatitis by suppressing NLRP3 inflammasome activation via targeting Caspase-1 in mice
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 17
作者:
Xia, Ling-yan
;
Yu, Nai-rong
;
Huang, Su-ling
;
Qu, Hui
;
Qin, Li
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2025/06/23
non-alcoholic steatohepatitis
dehydrotrametenolic acid methyl ester
NLRP3 inflammasome
caspase-1
macrophage-hepatocyte/HSC crosstalk
The combination of BET and METTL3 inhibitors elicits synergistic antitumor effects in ovarian cancer cells
via
reducing SP1 and BCL-2 expression
期刊论文
OAI收割
LIFE SCIENCES, 2025, 卷号: 368, 页码: 14
作者:
Ou, Ying-Jie
;
Liu, Ben-Jin
;
Xuan, Yi-Fei
;
Bao, Xu-Bin
;
Huan, Xia-Juan
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2025/04/24
BET inhibitor
METTL3 inhibitor
Combination therapy
SP1
BCL-2
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 9
作者:
Wang, Ze-chen
;
Zeng, Yue
;
Sun, Jin-yuan
;
Chen, Xue-qin
;
Wu, Hao-chen
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2025/04/24
deep learning
scoring function
GluN1/GluN3A receptor
N
-methyl-
D
-aspartate (NMDA) receptor
virtual screening
drug discovery
Synthesis, fluorescence properties of novel thiazolo[3,2-b][1,2,4]triazol derivatives as potent SHP2 inhibitors and its uses in sensing for Fe3+and cell imaging
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2025, 卷号: 1324, 页码: 12
作者:
Yan, Xue
;
Zhang, Chun
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Gan, Su-Ya
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2025/01/14
Thiazolo[3,2-b][1,2,4]triazole
Salicylic acid
Fe3+ion
Fluorescence property
SHP2
Study of the ameliorative effect of (3-Bisabolene on ischemic stroke via COX-2 with the Keap1/Nrf2 and MAPK pathways
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACOLOGY, 2025, 卷号: 1001
作者:
Zhang, Xingfang
;
Gao, Liang
;
Wang, Jianv
;
Zhang, Wei
;
Xu, Dong
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/11/27
(3-Bisabolene
Ischemic stroke
COX-2
Keap1/Nrf2 pathway
MAPK pathway
(3-Bisabolene
Ischemic stroke
COX-2
Keap1/Nrf2 pathway
MAPK pathway
Growth, structure and spectroscopic properties investigation on a novel Tm
3+
-doped disordered Ca(Gd
x
Y
1-x
)Al
3
O
7
hybrid melilite crystal
期刊论文
OAI收割
JOURNAL OF ALLOYS AND COMPOUNDS, 2024, 卷号: 1007
作者:
Deng, Guoliang
;
Xu, Min
;
Liu, Xingkun
;
Fang, Qiannan
;
Quan, Cong
  |  
收藏
  |  
浏览/下载:163/0
  |  
提交时间:2024/11/20
Disordered structure
Spectroscopic properties
Optical broadening-2 mu m laser
Tm:Ca( Gdx Y1-x )Al (3) O- 7 crystal
Tm:Ca( Gdx Y1-x )Al (3) O- 7 crystal