中国科学院机构知识库网格系统: 检索

浏览/检索结果: 共8条，第1-8条

帮助

条数/页：排序方式：
	Novel inhibitors of AChE and A0 aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235, 页码: 22 作者: Liu, Yulin; Uras, Giuseppe; Onuwaje, Itse; Li, Wenlong; Yao, Hong \| 收藏 \| 浏览/下载：53/0 \| 提交时间：2022/08/16 Alzheimer's disease Donepezil Sulfone group AChE inhibitor Inhibiting A 0 aggregation Neuroprotection
	Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation 期刊论文 OAI收割 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 5, 页码: 521-530 作者: Jiang, Cheng-Shi; Ge, Yong-Xi; Cheng, Zhi-Qiang; Song, Jia-Li; Wang, Yin-Yin \| 收藏 \| 浏览/下载：38/0 \| 提交时间：2020/07/01 AChE inhibitor Pharmacophore model Molecular docking Anti-A aggregation Neuroprotective activity
	Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease 期刊论文 OAI收割 ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345 作者: Mao, Fei; Wang, Huan; Ni, Wei; Zheng, Xinyu; Wang, Manjiong \| 收藏 \| 浏览/下载：62/0 \| 提交时间：2019/01/08 Alzheimer's disease drug repositioning dual-target inhibitor AChE inhibition PDE5 inhibition
	Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease 期刊论文 OAI收割 ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 7, 页码: 976-982 作者: Jia, Jing-ying; Zhao, Qian-hua; Liu, Yun; Gui, Yu-zhou; Liu, Gang-yi \| 收藏 \| 浏览/下载：18/0 \| 提交时间：2019/01/08 ZT-1 huperzine A prodrug AChE inhibitor drug tolerance pharmacokinetics Alzheimer's disease
	phaseistudyonthepharmacokineticsandtoleranceofzt1aprodrugofhuperzineaforthetreatmentofalzheimersdisease 期刊论文 OAI收割 actapharmacologicasinica, 2013, 卷号: 34, 期号: 7, 页码: 976 作者: Jia Jingying; Zhao Qianhua; Liu Yun; Gui Yuzhou; Liu Gangyi \| 收藏 \| 浏览/下载：22/0 \| 提交时间：2020/07/01 CHOLINESTERASE INHIBITOR CHOLINERGIC HYPOTHESIS PROGRESS RAT MEDICINE VITRO DRUG ZT-1 huperzine A prodrug AChE inhibitor drug tolerance pharmacokinetics Alzheimer's disease
	基于AChE多作用位点的氨基甲酸酯类和有机磷类化合物的设计、合成与生物活性测定学位论文 OAI收割博士, 北京: 中国科学院研究生院, 2009 赵前飞收藏 \| 浏览/下载：67/0 \| 提交时间：2010/06/24 簇合效应原理乙酰胆碱酯酶（AChE）乙酰胆碱酯酶抑制剂（AChEI）氨基甲酸酯类化合物有机磷类化合物离体活性活体活性 cluster effect acetylcholinesterase (AChE) acetylcholinesterase inhibitor (AChEI) carbamate compounds organophosphorus compounds activities in vitro activities in vivo
	Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase 期刊论文 OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 卷号: 17, 期号: 4, 页码: 1600-1613 作者: Zhu, Yiping; Xiao, Kun; Ma, Lanping; Xiong, Bin; Fu, Yan \| 收藏 \| 浏览/下载：21/0 \| 提交时间：2019/01/08 AD AChE BACE-1 Dual inhibitor HE HMC HEA
	Preparation of AChE inhibitors from jujubogenin 期刊论文 OAI收割 CHINESE CHEMICAL LETTERS, 2000, 卷号: 11, 期号: 8, 页码: 671-674 作者: Zhao, Y; Ku, YL; Lee, SS \| 收藏 \| 浏览/下载：22/0 \| 提交时间：2012/03/21 Alzheimer Disease (Ad) Acetylcholinesterase Ache Inhibitor Pharmaceutical Chemistry Jujubogenin Territrem b Analogues