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• 上海药物研究所 [95]
• 昆明植物研究所 [10]
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• 上海生物化学与细胞生... [4]
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• OAI收割 [134]
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• 期刊论文 [135]
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• 2024 [9]
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学科主题

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浏览/检索结果: 共136条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Drug discovery targeting thyroid hormone receptor f3 (THRf3) for the treatment of liver diseases and other medical indications 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 35-51 作者:  Wang, Kean;  Chen, Feiyang;  Wang, Jiang;  Liu, Hong   |  收藏  |  浏览/下载：8/0  |  提交时间：2025/04/01 Thyroid hormone  Thyroid hormone /3 receptor  MASLD  MASH  THR/3 agonist   Synergistic immune augmentation enabled by covalently conjugating TLR4 and NOD2 agonists 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 278, 页码: 15 作者:  Ding, Dong;  Gao, Runing;  Lei, Yujuan;  Liu, Jianing;  Zhou, Chengkai   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/10/21 TLR4 agonist  NOD2 agonist  Adjuvant  Covalent conjugation  Subunit vaccine   The antidepressant-like effect and proposed mechanism of action of TPN672MA, a novel serotonin-dopamine receptor modulator for the treatment of schizophrenia 期刊论文  OAI收割 PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2024, 卷号: 242, 页码: 13 作者:  Cheng, Jiaxin;  Wu, Chunhui;  Wang, Yu;  Wang, Zhen;  He, Yang   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/09/24 TPN672MA  5-HT 1A receptor agonist  D 2 /D 3 receptor partial agonist  5-HT 2A receptor antagonist  Antidepressant-like  Mechanism   FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2024, 页码: 15 作者:  Wen, Ying-quan;  Zou, Zi-yuan;  Zhao, Guan-guan;  Zhang, Meng-jiao;  Zhang, Yong-xin   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/08/22 MASLD/MASH  FXR  transcriptome  gut-liver axis  agonist   Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 26, 页码: 10 作者:  Li, Jingru;  You, Chongzhao;  Li, Yang;  Li, Changyao;  Fan, Wenjia   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/08/22 SSTR5  peptide agonists  agonist selectivity  receptor activation   A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 107, 页码: 19 作者:  Wang, Xiaoyan;  Yun, Ying;  Chen, Lili;  Guo, Shimeng;  Niu, Buying   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/07/12 Diabetes  GLP-1 receptor  Agonist  Structural optimization  Water molecule replacement  Structure activity relationship  Docking simulation   Design, Synthesis and Bioactivity of NYX-2925 L-Proline Derivatives as N-Methyl-D-aspartate (NMDA) Receptor Partial Agonists 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 4, 页码: 1247-1263 作者:  Wu Youjin;  Jin Zhengsheng;  Liu Yongjia;  Huang Wenqian;  Zhao Guilong   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/08/22 N-methyl-D-aspartate (NMDA) receptor  partial agonist  NYX-2925  synthesis  bioactivity   Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18 作者:  Zhuo, Ning;  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Yin, Jianpeng   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/03/25 Type 2 Diabetes  TGR5 agonist  Betulinic acid  Gut-restricted  Gallbladder-filling effects  Kinetophores   Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20 作者:  Yang, Wenjiao;  Gong, Xudong;  Sun, Haiguo;  Wu, Chunhui;  Suo, Jin   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/03/06 CB2R agonist  5-HT1AR agonist  CB1R antagonist  Antidepressant  Anxiolytic   Application of ensemble learning for predicting GABAA receptor agonists 期刊论文  OAI收割 COMPUTERS IN BIOLOGY AND MEDICINE, 2024, 卷号: 169, 页码: 13 作者:  Xiao, Fu;  Ding, Xiaoyu   |  收藏  |  浏览/下载：34/0  |  提交时间：2024/03/25 GABA(A )receptor  Benzodiazepine  Agonist  Machine learning  Classification