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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
水生生物研究所 [6]
武汉植物园 [2]
西双版纳热带植物园 [1]
昆明植物研究所 [1]
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OAI收割 [10]
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期刊论文 [10]
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Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis
期刊论文
OAI收割
JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA, 2014, 卷号: 26, 期号: 9, 页码: 1930-1935
作者:
Huang, Wenmin
;
Li, Dunhai
;
Liu, Yongding
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2015/01/20
Microcystin-RR
Tobacco BY-2 cells
Apoptosis
Reactive oxygen species
Mitochondrial electron transport chain
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
Improved expression and purification of recombinant human serum albumin from transgenic tobacco suspension culture
期刊论文
OAI收割
JOURNAL OF BIOTECHNOLOGY, 2011, 卷号: 155, 期号: 2, 页码: 164-172
Qiao-Yang Sun
;
Ling-Wen Ding
;
George P. Lomonossoff
;
Yong-Bing Sun
;
Ming Luo
;
Chao-Qiong Li
;
Liwen Jiang
;
Zeng-Fu Xu∗
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2012/04/05
BY-2 cells
pEAQ
Plant suspension culture
Recombinant HSA
Signal peptide
Morphological and ultrastructural changes in tobacco BY-2 cells exposed to microcystin-RR
期刊论文
OAI收割
CHEMOSPHERE, 2009, 卷号: 76, 期号: 7, 页码: 1006-1012
作者:
收藏
  |  
浏览/下载:124/0
  |  
提交时间:2010/10/13
Microcystin-RR
Tobacco BY-2 cells
Morphology
Ultrastructure
Apoptosis
Necrosis
The role of glutathione metabolism in tolerance of tobacco BY-2 suspension cells to microcystin-RR
期刊论文
OAI收割
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2008, 卷号: 80, 期号: 3, 页码: 215-219
作者:
Huang, Wen Min
;
Xing, Wei
;
Li, Dun Hai
;
Liu, Yong Ding
收藏
  |  
浏览/下载:50/2
  |  
提交时间:2010/10/13
Microcystin-RR
tobacco BY-2 suspension cells
glutathione metabolism
oxidative stress
Microcystin-RR induced apoptosis in tobacco BY-2 suspension cells is mediated by reactive oxygen species and mitochondrial permeability transition pore status
期刊论文
OAI收割
TOXICOLOGY IN VITRO, 2008, 卷号: 22, 期号: 2, 页码: 328-337
作者:
Huang, Wenmin
;
Xing, Wei
;
Li, Dunhai
;
Liu, Yongding
收藏
  |  
浏览/下载:101/3
  |  
提交时间:2010/10/13
MC-RR
tobacco BY-2 suspension cells
apoptosis
ROS
PTP
Microcystin-RR induced apoptosis in tobacco BY-2 suspension cells is mediated by reactive oxygen species and mitochondrial permeability transition pore status
期刊论文
OAI收割
TOXICOLOGY IN VITRO, 2008, 卷号: 22, 期号: 2, 页码: 328-337
作者:
Li, Dunhai
;
Huang, Wenmin
;
Xing, Wei
;
Liu, Yongding
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2017/04/13
MC-RR
tobacco BY-2 suspension cells
apoptosis
ROS
PTP
The role of glutathione metabolism in tolerance of tobacco BY-2 suspension cells to microcystin-RR
期刊论文
OAI收割
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2008, 卷号: 80, 期号: 3, 页码: 215-219
作者:
Li, Dun Hai
;
Huang, Wen Min
;
Xing, Wei
;
Liu, Yong Ding
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2017/04/13
Microcystin-RR
tobacco BY-2 suspension cells
glutathione metabolism
oxidative stress
Microcystin-RR-induced apoptosis in tobacco BY-2 cells
期刊论文
OAI收割
TOXICON, 2006, 卷号: 48, 期号: 2, 页码: 204-210
作者:
Yin, Liyan
;
Huang, Jiaquan
;
Li, Wei
;
Liu, Yongding
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2010/10/13
microcystin-RR
tobacco BY-2 cells
apoptosis
flow cytometry
transmission electron microscopy
Microcystin-RR-induced accumulation of reactive oxygen species and alteration of antioxidant systems in tobacco BY-2 cells
期刊论文
OAI收割
TOXICON, 2005, 卷号: 46, 期号: 5, 页码: 507-512
作者:
Yin, LY
;
Huang, JQ
;
Huang, WM
;
Li, DH
;
Wang, GH
收藏
  |  
浏览/下载:58/2
  |  
提交时间:2010/10/13
microcystin-RR
tobacco BY-2 cells
reactive oxygen species
peroxide dismutase
glutathione peroxide
superoxide dismutase
catalase