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Chinese Academy of Sciences Institutional Repositories Grid
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Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis 期刊论文  OAI收割
JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA, 2014, 卷号: 26, 期号: 9, 页码: 1930-1935
作者:  
Huang, Wenmin;  Li, Dunhai;  Liu, Yongding
收藏  |  浏览/下载:31/0  |  提交时间:2015/01/20
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  
Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
收藏  |  浏览/下载:47/0  |  提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.  
Improved expression and purification of recombinant human serum albumin from transgenic tobacco suspension culture 期刊论文  OAI收割
JOURNAL OF BIOTECHNOLOGY, 2011, 卷号: 155, 期号: 2, 页码: 164-172
Qiao-Yang Sun; Ling-Wen Ding; George P. Lomonossoff; Yong-Bing Sun; Ming Luo; Chao-Qiong Li; Liwen Jiang; Zeng-Fu Xu∗
收藏  |  浏览/下载:19/0  |  提交时间:2012/04/05
Morphological and ultrastructural changes in tobacco BY-2 cells exposed to microcystin-RR 期刊论文  OAI收割
CHEMOSPHERE, 2009, 卷号: 76, 期号: 7, 页码: 1006-1012
作者:  
收藏  |  浏览/下载:124/0  |  提交时间:2010/10/13
The role of glutathione metabolism in tolerance of tobacco BY-2 suspension cells to microcystin-RR 期刊论文  OAI收割
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2008, 卷号: 80, 期号: 3, 页码: 215-219
作者:  
Huang, Wen Min;  Xing, Wei;  Li, Dun Hai;  Liu, Yong Ding
收藏  |  浏览/下载:50/2  |  提交时间:2010/10/13
Microcystin-RR induced apoptosis in tobacco BY-2 suspension cells is mediated by reactive oxygen species and mitochondrial permeability transition pore status 期刊论文  OAI收割
TOXICOLOGY IN VITRO, 2008, 卷号: 22, 期号: 2, 页码: 328-337
作者:  
Huang, Wenmin;  Xing, Wei;  Li, Dunhai;  Liu, Yongding
收藏  |  浏览/下载:101/3  |  提交时间:2010/10/13
Microcystin-RR induced apoptosis in tobacco BY-2 suspension cells is mediated by reactive oxygen species and mitochondrial permeability transition pore status 期刊论文  OAI收割
TOXICOLOGY IN VITRO, 2008, 卷号: 22, 期号: 2, 页码: 328-337
作者:  
Li, Dunhai;  Huang, Wenmin;  Xing, Wei;  Liu, Yongding
  |  收藏  |  浏览/下载:12/0  |  提交时间:2017/04/13
The role of glutathione metabolism in tolerance of tobacco BY-2 suspension cells to microcystin-RR 期刊论文  OAI收割
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2008, 卷号: 80, 期号: 3, 页码: 215-219
作者:  
Li, Dun Hai;  Huang, Wen Min;  Xing, Wei;  Liu, Yong Ding
  |  收藏  |  浏览/下载:23/0  |  提交时间:2017/04/13
Microcystin-RR-induced apoptosis in tobacco BY-2 cells 期刊论文  OAI收割
TOXICON, 2006, 卷号: 48, 期号: 2, 页码: 204-210
作者:  
Yin, Liyan;  Huang, Jiaquan;  Li, Wei;  Liu, Yongding
收藏  |  浏览/下载:77/0  |  提交时间:2010/10/13
Microcystin-RR-induced accumulation of reactive oxygen species and alteration of antioxidant systems in tobacco BY-2 cells 期刊论文  OAI收割
TOXICON, 2005, 卷号: 46, 期号: 5, 页码: 507-512
作者:  
Yin, LY;  Huang, JQ;  Huang, WM;  Li, DH;  Wang, GH
收藏  |  浏览/下载:58/2  |  提交时间:2010/10/13