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	Rotundic acid induces Cas3-MCF-7 cell apoptosis through the p53 pathway 期刊论文 OAI收割 Oncology Letters, 2019, 卷号: 17, 期号: 1, 页码: 630-637 作者: M.L.Nan; X.Wang; H.J.Li; D.H.Yu; W.Y.Sun \| 收藏 \| 浏览/下载：29/0 \| 提交时间：2020/08/24 rotundic acid,apoptosis,p53,MCF-7 cells,breast-cancer cells,triterpene acids,caspase 3,expression,reconstitution,proteins,protects,trial,Oncology
	Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文 OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者: Zeng, Guang-Zhi; Fan, Jun-Ting; Xu, Jun-Ju; Li, Yan; Tan, Ning-Hua 收藏 \| 浏览/下载：44/0 \| 提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA) one of the major components isolated from the traditional Chinese medicine Rubia yunnanensis exhibited inhibitory activity on the proliferation of several human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle arrest in human cervical carcinoma HeLa cells. Further MTA was found to induce apoptosis of HeLa cells through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and release of cytochrome c into the cytosol which caused the cleavage of caspase and poly(ADP-ribose) polymerase and finally triggered the apoptosis. Furthermore the p53/p21/Cdc2-cyclin B1 signaling was found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of R. yunnanensis a folk anti-cancer herb used in Yunnan China.
	Antitumor activity of folate-targeted, paclitaxel-loaded polymeric micelles on a human esophageal EC9706 cancer cell line 期刊论文 OAI收割 international journal of nanomedicine, 2012, 卷号: 7, 页码: 3487-3502 Wu WB; Zheng YH; Wang R; Huang WL; Liu L; Hu XL; Liu S; Yue J; Tong T; Jing XB 收藏 \| 浏览/下载：26/0 \| 提交时间：2013/06/30 PHASE-II TRIAL IN-VITRO BLOCK-COPOLYMER CASPASE-3 EXPRESSION RADIATION-THERAPY UP-REGULATION CARCINOMA CHEMORADIOTHERAPY APOPTOSIS BAX
	Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells 期刊论文 OAI收割 ACTA PHARMACOLOGICA SINICA, 2011, 卷号: 32, 期号: 10, 页码: 1266-1275 作者: Zhang Yahong; Wu Yingliang; Tashiro Shinichi; Onodera Satoshi; Ikejima Takashi \| 收藏 \| 浏览/下载：8/0 \| 提交时间：2021/02/02 MITOCHONDRIAL PERMEABILITY TRANSITION OXIDATIVE STRESS MEDIATED AUTOPHAGY CANCER DEATH ACTIVATION MECHANISM EXPRESSION GENERATION INDUCTION oridonin reactive oxygen species apoptosis autophagy Bax Bcl-2 caspase 3 caspase 8 HeLa cell
	Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury 期刊论文 OAI收割 NEURAL REGENERATION RESEARCH, 2010, 卷号: 5, 期号: 17, 页码: 1296-1302 作者: Fan Hongjie; Yu Weidong; Wang Zongli; Wang Qian; He Zhiyi \| 收藏 \| 浏览/下载：18/0 \| 提交时间：2021/02/02 STROMAL CELLS ARTERY OCCLUSION RAT MODEL ISCHEMIA BRAIN TRANSPLANTATION STROKE APOPTOSIS DIFFERENTIATION EXPRESSION bone marrow-derived mesenchymal stem cells cerebral ischemia/reperfusion survivin caspase-3 cell apoptosis brain injury neural regeneration
	Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury 期刊论文 OAI收割 NEURAL REGENERATION RESEARCH, 2010, 卷号: 5, 期号: 17, 页码: 1296-1302 作者: Fan Hongjie; Yu Weidong; Wang Zongli; Wang Qian; He Zhiyi \| 收藏 \| 浏览/下载：22/0 \| 提交时间：2021/02/02 STROMAL CELLS ARTERY OCCLUSION RAT MODEL ISCHEMIA BRAIN TRANSPLANTATION STROKE APOPTOSIS DIFFERENTIATION EXPRESSION bone marrow-derived mesenchymal stem cells cerebral ischemia/reperfusion survivin caspase-3 cell apoptosis brain injury neural regeneration