机构

• 上海药物研究所 [7]
• 昆明植物研究所 [2]
• 上海生物化学与细胞生... [1]
• 昆明动物研究所 [1]

采集方式

• OAI收割 [11]

内容类型

• 期刊论文 [11]

发表日期

• 2023 [1]
• 2021 [2]
• 2019 [2]
• 2018 [2]
• 2014 [1]
• 2009 [2]
• 更多

学科主题

• Oncology [1]
• Science & ... [1]

筛选

浏览/检索结果: 共11条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design, Synthesis, and Biological Evaluation of 2-Aminothiazole Derivatives as Novel Checkpoint Kinase 1 (CHK1) Inhibitors 期刊论文  OAI收割 CHEMMEDCHEM, 2023, 页码: 19 作者:  Deng, Minjie;  Wang, Peipei;  Long, Xiubing;  Xu, Gaoya;  Wang, Chang   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/04/10 2-aminothiazole  CHK1 inhibitors  antiproliferation  hematologic malignancies  biological activity   Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Jiang, Kai-long;  Tong, Le-xian;  Wang, Tao;  Wang, Han-lin;  Hu, Xiao-bei   |  收藏  |  浏览/下载：59/0  |  提交时间：2021/05/24 CHK1 inhibitors  PY34  drug sensitivity  c-Myc  hematologic malignancies   Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia 期刊论文  OAI收割 CHEMMEDCHEM, 2021, 页码: 12 作者:  Jin, Tingting;  Wang, Peipei;  Long, Xiubing;  Jiang, Kailong;  Song, Pinrao   |  收藏  |  浏览/下载：134/0  |  提交时间：2021/05/24 CHK1 inhibitor  diaminopyrimidine  DNA damage response  oral bioavailability   Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62 作者:  Tong, Lexian;  Song, Pinrao;  Jiang, Kailong;  Xu, Lei;  Jin, Tingting   |  收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 CHK1 kinase inhibitor  Selectivity  Monotherapy  Hematologic malignancies   Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文  OAI收割 TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83 作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan   |  收藏  |  浏览/下载：86/0  |  提交时间：2019/03/18 Acetyl-macrocalin B  Reactive oxygen species  p38 MAPK  Chk1/Chk2  Esophageal squamous cell carcinoma   Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer 期刊论文  OAI收割 CANCER BIOLOGY & THERAPY, 2018, 卷号: 19, 期号: 7, 页码: 609-621 作者:  Wang, Jing-Nan;  Zhang, Zhi-Rong   |  收藏  |  浏览/下载：122/0  |  提交时间：2018/07/16 Acetyl-macrocalin B  reactive oxygen species  p38 MAPK  apoptosis  Chk1  Chk2  G2  M phase arrest  NSCLC   RNF126 as a biomarker of a poor prognosis in invasive breast cancer and CHK1 inhibitor efficacy in breast cancer cells 期刊论文  OAI收割 Clinical Cancer Research, 2018, 卷号: 24, 期号: 7, 页码: 1629-1643 作者:  Shanhuai Ma;  Pengyan Fa;  Zhefu Ma;  Hongbing Wang;  Yao Zhang   |  收藏  |  浏览/下载：54/0  |  提交时间：2018/09/28 Rnf126  Chk1  Replication Stress  Breast Cancer  Target Therapy   Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 17, 页码: 4882-4892 作者:  Song, Pinrao;  Peng, Peng;  Han, Mengmeng;  Cao, Xianchao;  Ma, Xiaodong   |  收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 Chk1 inhibitor  Thienopyridinones  Antitumor  Cell synergy   Chk1 prevents abnormal mitosis of S-phase HeLa cells containing DNA damage 期刊论文  OAI收割 CHINESE SCIENCE BULLETIN, 2009, 卷号: 54, 期号: 22, 页码: 4205-4213 作者:  Li, XF;  Ward, T;  Yao, XB;  Wu, JR 收藏  |  浏览/下载：29/0  |  提交时间：2015/07/22 cell cycle  DNA damage checkpoint  DNA replication checkpoint  Chk1  methyl methanesulfnate